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OBJECTIVE: Lipid levels and the entire C-reactive protein (hs-CRP) level are closely associated with eerebrovascular disease.Cerebral ischemia and hypoxia and chronic inflammation caused by the bodys stress response is caused to basic dementia onset of pathological processes.Brazilian propolis has potential protective effects on hypoxia-induced neuroinflammatory responses by microglia.This study was to investigate the effects of Brazilian propolis on the metabolism of hs-CRP and lipid with mild cognitive impairment (MCI) patients.