论文部分内容阅读
Understanding the function and control of oncogenic signaling pathways is fundamental to finding a cure for cancer.Despite recent advances in cancer research and treatment,neither the complex signaling networks in cancer cells nor the initiation and progression of tumorigenesis are completely understood.We provided new insights into the multi-faceted functions of the tumor suppressor 14-3-3σ in protecting cells from tumorigenic transformation.14-3-3σ is known to control cell cycle progression.Our analysis indicates that the loss of14-3-3σ expression in breast cancer cases reduced the patientsoverall and recurrence-free survival.Results of our studies in breast cancer cell lines, murine xenograft tumors, and human breast tumors revealed previously unknown activities of14-3-3σ in suppressing major cancer hallmarks, especially the deregulation of cellular energetics.14-3-3σ inhibited cancer metabolic reprogramming by promoting Myc degradation,thereby reversing the oncogenic changes in cellular bioenergetics of tumors.Thus, this tumor suppressor could be considered as a potential target for the future development of targeted anticancer therapies.