【摘 要】
：
Objectives: Prostate cancer is the second leading cause of cancer mortality among men in the U.S.To the authorsknowledge, there was no improved, second-line therapy for metastatic hormone refractory p
【机 构】
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Department of Urology Bellland General Hospital Japan
【出 处】
：
BIT Life Sciences 1st Annual World Cancer Congess-2008(2008中
论文部分内容阅读
Objectives: Prostate cancer is the second leading cause of cancer mortality among men in the U.S.To the authorsknowledge, there was no improved, second-line therapy for metastatic hormone refractory prostate cancer (HRPC).Recent data suggest that docetaxel-based chemotherapy has be effective in HRPC.Combination chemotherapy using carboplatin and weekly docetaxel was examined in Japanese patients with metastatic HRPC.Methods: Eligible men had metastatic prostate cancer that had progressed after hormonal therapy.Patients were treated with intravenous docetaxel at a dose of 25 mg/m2 (Day 1, 8, 15) plus carboplatin (AUC4, Day 1) every 4 weeks until they had either disease progression or unacceptable toxicity.The primary end point was prostate-specific antigen (PSA) response.Results: A total of 23 patients were evaluable for this study.The PSA partial objectiye response rate was 65.2% (15 patients).The median duration of PSA response was 7.8 months.Grade 3 leukopenia occurred in only 8.7% of patients.No grade 4 adverse events were admitted in this study.Conclusions: The combination chemotherapy using carboplatin and weekly docetaxel was effective without severe toxicity in patients with metastatic HRPC.
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