【摘 要】
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Background: Peptidoglycan (PGN), the major cell wall component of Gram-positive bacteria, is known to elicit excessive proinflammatory cytokine production from immune cells.Mannan-binding lectin (MBL)
【机 构】
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Xinxiang Medical University
【出 处】
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中国免疫学会第九届全国免疫学学术大会
论文部分内容阅读
Background: Peptidoglycan (PGN), the major cell wall component of Gram-positive bacteria, is known to elicit excessive proinflammatory cytokine production from immune cells.Mannan-binding lectin (MBL), a plasma C-type lectin,plays a key role in innate immunity.Toll-like receptor 2 (TLR2) is abundantly expressed on immune cells, and has been shown to be involved in PGN-induced signaling.In this study, we first investigated whether MBL altered PGN-elicited cellular responses in phorbol 12-myristate 13-acetate (PMA)-activated human THP-1 macrophages, and then investigated the possible mechanism.
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