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5. PARP1 negatively regulates SIRT6 activity by PARylation of SIRT6 during cardiac remodeling

PARP1 negatively regulates SIRT6 activity by PARylation of SIRT6 during cardiac remodeling

来源 :中国药理学会北美分会药理学学术大会 | 被引量 : 0次 | 上传用户：slie726

【摘 要】

：

The present study aimed to observe the interaction between Poly(ADP-ribose)polymerase 1(PARP1)and sirtuin 6 deacetylase(SIRT6)in cardiac remodeling.Both PARP1 and SIRT6 are important NAD+-dependent en

【作 者】

：

Guo-shuai FENG Zhuo-ming LI Shao-rui CHEN Pei-qing LIU 

【机 构】

：

Department of Pharmacology and Toxicology,School of Pharmaceutical Sciences,Sun Yat-Sen University,G

【出 处】

：

中国药理学会北美分会药理学学术大会

【发表日期】

：

2017年10期

【关键词】

：

PARP1 SIRT6 PARylation cardiac remodeling 

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　　The present study aimed to observe the interaction between Poly(ADP-ribose)polymerase 1(PARP1)and sirtuin 6 deacetylase(SIRT6)in cardiac remodeling.Both PARP1 and SIRT6 are important NAD+-dependent enzymes.Accumulating evidences indicated both PARP1 and SIRT6 were involved in cardiac diseases.

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