【摘 要】
：
流感病毒感染能引起地区性流行和全球大流行.有效的抗病毒治疗时间是开始出现症状的48小时内,超过这个时间的延迟治疗会导致疗效下降.改善流感引起的炎症的抗炎治疗研究还在进行中,应该会对临床治疗结果产生影响.具有新靶点的抗病毒和抗炎药物亟待发现.目前抗流感药物的疗效评价方法主要依靠转化细胞和实验动物.可是,转化细胞模型是远离生理和病理条件.虽然动物实验是临床前药物评价的最好选择,但是比较费时费钱.在本研
【机 构】
：
病毒学国家重点实验室,中国科学院武汉病毒研究所,武汉 43001;中国科学院大学,北京 100049
【出 处】
：
第十一届全国病毒学学术研讨会暨第六届武汉现代病毒学国际研讨会
论文部分内容阅读
流感病毒感染能引起地区性流行和全球大流行.有效的抗病毒治疗时间是开始出现症状的48小时内,超过这个时间的延迟治疗会导致疗效下降.改善流感引起的炎症的抗炎治疗研究还在进行中,应该会对临床治疗结果产生影响.具有新靶点的抗病毒和抗炎药物亟待发现.目前抗流感药物的疗效评价方法主要依靠转化细胞和实验动物.可是,转化细胞模型是远离生理和病理条件.虽然动物实验是临床前药物评价的最好选择,但是比较费时费钱.在本研究中,我们建立了一个使用鼠标肺片体外模型用于评价抗病毒和抗炎药对流感病毒感染的治疗作用.
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