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MicroRNAs (miRNAs) are involved in human cancer including non-small celllung cancer (NSCLC).In this study,we compared miRNA expression microarrayof SPC-A-1sci (high metastatic) and SPC-A-1 (weakly metastatic) cells.We foundthat miRNA-10a was up-regulated in NSCLC compared with corresponding normaltissues.High expression of miR-10a was associated with tumor node metastasis andlymph node metastasis.Furthermore,overexpression of miR-10a promoted NSCLCcell proliferation,migration and invasion in vitro.We found that PTEN was a directtarget of miR-10a in NSCLC.Also miR-10a activated the PTEN/AKT/ERK pathway.Wesuggest that miR-10a contributes to NSCLC by targeting PTEN.