【摘 要】
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Among various N-heterocycles,reduced and oxidized forms of pyrrolo[1,2-a]quinolines occur widely among natural products,and exhibit a wide array of biologic
【机 构】
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Department of Chemistry,Shanghai University,Shanghai 200444,China
【出 处】
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中国化学会全国第十二届有机合成化学学术研讨会
论文部分内容阅读
Among various N-heterocycles,reduced and oxidized forms of pyrrolo[1,2-a]quinolines occur widely among natural products,and exhibit a wide array of biological activities1,2.In particular,fluorine-containing pyrrolo[1,2-a]quinolines are less reported.Herein we report the efficient synthesis of 3-carbonyl-1-perfluoroalkylpyrrolo[1,2-a]quinolines via two-step copper-catalyzed reactions.We performed the reaction by employing quinoline 1,terminal aryne 2 and perfluoroalk-2-ynoate 3 in the presence of 5 mol-%of CuI in DCM.After stirring for 36 h at r.t.,CuBr2,DMAP and DMSO were added,and the mixture was stirred at 80°C for an additional 24 h.A series of substituted pyrrolo[1,2-a]quinolines 4 were synthesized in moderate to high yields(Table 1).
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