新生儿重症高胆红素血症分层风险评估模型的建立和验证

来源 :第五届上海国际新生儿医学论坛 | 被引量 : 0次 | 上传用户:mcusun
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Objective To develop and validate a predischarge risk-stratification model from transcutaneous bilirubin (TcB)values and clinical factors to predict significant post-discharge hyperbilirubinemia in healthy term and late-preterm Chinese neonates.Methods In a prospective cohort study, 8215 healthy term and late-preterm neonates in eight hospitals in China underwent TcB measurement before 168 hours of age.TcB percentiles were calculated and used to develop an hour-specific nomogram.Nine empirically weighted items were used to derive a prediction model.A risk-stratification model was developed by combining the TcB nomogram with clinical risk scores to guide subsequent follow up plan.Data from another 13157 neonates were used to validate the model.
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