Chromc inflammation is an underlying factor in the development and progression ofcancers.Nuclear factor-kappa B (NF-κB) and activator protein-1 (AP-1) are the important transcription factorsthat promote the expression ofpro-infammatory enzymes, cyclooxygenase-2 (COX-2), which contribute to cells inflammatory responses.2-Methoxy-1,4-Naphthoquinone (MNQ), isolated from pericarps of Impatiens balsamina Linn.