【摘 要】
：
Objectives:To study the role of Muscone in the 1VD degeneration with the focuses on the vasculature,inflammation and apoptosis in the endplate cartilage.Methods:In vivo investigation of Muscone effect
【机 构】
：
上海中医药大学脊柱病研究所,上海,200032 上海中医药大学附属龙华医院,上海,200032
【出 处】
：
2007SICOT国际矫形外科学术会议(SICOT-SIROT SHANGHAI CONGRESS 2007)
论文部分内容阅读
Objectives:To study the role of Muscone in the 1VD degeneration with the focuses on the vasculature,inflammation and apoptosis in the endplate cartilage.Methods:In vivo investigation of Muscone effect on the degeneration of intervertebral discs (IVD) in a rat model of the surgery-induced cervical spine instability.By excising the paraspinal musculature and posterior cervical spinal ligaments of rats,both static and dynamic cervical forces were disrupted.After surgery,some rats were fed with Muscone.Histopathologic and biochemical features of IVD cells,especially chondrocytes in endplage cartilage,were examined with a series of methods including histology,in situ hybridization for TNF-,ELISA for IL-1,PGE2,and 6-keto-prostaglandin F1 alpha (6-K-PGF1),TUNEL staining,and immunostaining of Fas and bcl-2.
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