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Objective To evaluate the effect of Bear Bile Powder (BBP) on the tumor angiogenesis, and investigate the underlying molecular mechanisms.Methods MTT assay was performed to determine the viability of human umbilical vein endothelial cells (HUVECs).Cell cycle progression of HUVECs was examined by FACS analysis with PI staining.HUVEC migration was determined by wound healing method.An ECMatrix gel system was used to evaluate the tube formation of HUVECs.