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Signal transducer and activator of transcription 3 (STAT3) plays a critical role in cell survival and proliferation.Constitutive activation of STAT3 is strongly correlated with pathogenesis of various types of malignant tumor including colorectal cancer (CRC), and therefore becomes a major focus in the development of anti-cancer agents.Pien Tze Huang (PZH), a well-known traditional Chinese formula prescribed 450 years ago in the Ming Dynasty, has been demonstrated to be clinically effective in the treatment of CRC.However, the precise mechanism of its anti-cancer activity remains largely unknown.