【摘 要】
：
类金刚石薄膜(Diamond-like carbon,DLC)由于高硬度、耐磨性以及生物相容性而被广泛运用于人工关节表面改性.但在长期服役中DLC磨屑依然存在,且这些磨屑为尺寸不一、形态各异、结构不同(sp2/sp3)的纳米碳颗粒(Nano carbon particle,NCs).为了进一步促进DLC薄膜在人工关节改性的应用,DLC磨屑的生物相容性值得研究.由于DLC磨屑难于收集、且磨损量小,因
【机 构】
：
西南交通大学 材料学院,四川成都 610031
【出 处】
：
第十一届全国表面工程大会暨第八届全国青年表面工程学术会议
论文部分内容阅读
类金刚石薄膜(Diamond-like carbon,DLC)由于高硬度、耐磨性以及生物相容性而被广泛运用于人工关节表面改性.但在长期服役中DLC磨屑依然存在,且这些磨屑为尺寸不一、形态各异、结构不同(sp2/sp3)的纳米碳颗粒(Nano carbon particle,NCs).为了进一步促进DLC薄膜在人工关节改性的应用,DLC磨屑的生物相容性值得研究.由于DLC磨屑难于收集、且磨损量小,因此在早期研究中,我们拟通过体外模拟DLC磨屑,并评价其生物相容性.在本研究中,利用真空热处理方式制备不同结构的纳米碳颗粒,同时拉曼光谱(Raman spectrum)、X射线光电子能谱(X-ray photoelectron spectroscopy,XPS)、透射电子显微镜(Tran mission Electron microscope,TEM)以及动态光散射(Dyn mic Light Scattering,DLS)等技术表征其物理化学性质.结果 显示,通过真空热处理成功制备了与体内真实结构相似的纳米碳颗粒.纳米碳颗粒的sp2/sp3比例由0.165到0.856变化,且尺寸为10 nm左右,呈现圆形.同时Zeta电位为-25到-30 mV变化.利用成骨细胞和巨噬细胞进行体外实验对其生物相容性进行研究.结果表明,相较于CoCrMo颗粒,不同sp2/sp3比例的碳颗粒具有较好的成骨能力.巨噬细胞实验结果表明,纳米碳颗粒引起较低的炎症反应,释放较少的IL-6和TNF-α炎症因子.总的来说,相较于CoCrMo颗粒,不同sp2/sp3比例的纳米碳颗粒具有较好的成骨能力,引起较低的巨噬细胞炎症反应,呈现较好的生物相容性,这主要得益于纳米碳颗粒表面电学性质.
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