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Aim: Sulfur dioxide(S02)is naturally synthesized by glutamate-oxaloacetate transaminase(GOT)from L-cysteine in mammalian cells.We found that SO2 may have a protective effect on acute lung injury(ALI)induced by limb ischemia/reperfusion(I/R)in rats.The PI3K/Akt,p38MAPK and JAK2/STAT3 pathways are crucial in cell signaling transduction.They play an important role in many physiological and pathological process.The present study aim to verified the role of SO2 on limb I/R induced ALI,and investigate whether PI3K/Akt,p38MAPK and JAK2/STAT3 Pathways were involved,as well as the relationship among the three pathways.