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RNA interference(RNAi)is an siRNA-dependent gene silencing approach controlled by an RNA-induced silencing complex(RISC)which is mediated by a specialized family of RNA-binding proteins named Argonaute(Ago).We describe the use of gold nanoparticle(AuNP)-oligonucleotide probe as intracellular c-Myc oncogene regulation agents for the control of c-Myc protein expression in cells via disrupting RNAi pathway.