Adult hippocampal telomerase is implicated in mood disorders

来源 :The 12th Meeting of the Asia Pacific Federation of Pharmacol | 被引量 : 0次 | 上传用户：hai_john

【摘要】

：

【作者】

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Meng-ying LIU Dong-ya ZHU Qi-gang ZHOU Hai-yin WU Xin-ru SHEN Han-Woong LEE Sus(h)il DEVKOT Wan-Chul KIM Chen CHEN Yao HU Xin FENG

【机构】

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Department of Pharmacology, Pharmacy College, Nanjing Medical University, Nanjing, China

【出处】

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The 12th Meeting of the Asia Pacific Federation of Pharmacol

【发表日期】

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2013年4期

【关键词】

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telomerase hippocampus depression anxiety aggression

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Aim: The aim of the present study is to determine the role of adult hippocampal telomerase in the pathology of mood disorders.Methods: We constructed telomerase reverse transcriptase subunit (TERT) knockout mice, TERT RNA interference virus (LV-TERT-shRNA) and TERT overexpression virus (ADTERT), and used telomerase activity inhibitor AZT.

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Adult hippocampal telomerase is implicated in mood disorders

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