Aim: Obesity is associated with higher risk and with poor prognosis of cancer.We investigate the effects of PMQ on the metabolic disorders and the tumor growth in MSG-induced obese mice.Methods: MSG-induced obese mice model was established.At 5 week of age, all mice were randomized to ten groups (n=10 per group): Control and MSG model+vehicle, PMQ 5, 10, and 20 mg/kg/d, metformin 300 mg/kg/d respectively and administrated by gastric gavage for 19 weeks.were harvested.