【摘 要】
：
研究背景:T细胞稳态是指外周T细胞通过细胞存活及增殖等来维持自身数目平衡,从而行使正常的免疫功能.以往的实验数据表明外周T细胞的稳态主要依赖MHC-抗原肽及IL-7的相互作用.现在,越来越多的研究提示自噬在T细胞稳态中发挥重要作用.Binfeng Lu等在06年的研究发现小鼠primaryT细胞也存在一定水平的自噬,在TCR或某些细胞因子刺激及饥饿条件下T细胞自噬会显著升高.mTOR及caspas
【出 处】
：
中国免疫学会第九届全国免疫学学术大会
论文部分内容阅读
研究背景:T细胞稳态是指外周T细胞通过细胞存活及增殖等来维持自身数目平衡,从而行使正常的免疫功能.以往的实验数据表明外周T细胞的稳态主要依赖MHC-抗原肽及IL-7的相互作用.现在,越来越多的研究提示自噬在T细胞稳态中发挥重要作用.Binfeng Lu等在06年的研究发现小鼠primaryT细胞也存在一定水平的自噬,在TCR或某些细胞因子刺激及饥饿条件下T细胞自噬会显著升高.mTOR及caspases可显著抑制T细胞自噬,而class ⅢⅢ P3Ks和JNK MAPKs可增强T细胞自噬.在对Atg5,Atg7,Beclin-1等自噬基因缺陷的小鼠研究发现,与正常小鼠相比,这类小鼠外周T细胞数目显著降低且自发凋亡增多,细胞内环境紊乱,但胸腺T细胞发育基本无异常.提示自噬与T细胞存活及稳态有密切关系.
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