Oxymatrine (OM) can be metabolized to matrine in gastrointestinal ileocecal valve after oral administration, which affects pharmacological activity and reduce bioavailability of OM.A type of multiple-unit alginate-chitosan (Alg-Cs) floating microspheres was prepared by ionotropic gelation method for gastroretention delivery of OM.Solid dispersion technique was applied and incorporated into microspheres to enhance the OM encapsulation efficiency and sustain the drug release.