代谢性疾病的应激耐受假设和自由基调节

来源 :中华预防医学会自由基预防学专业委员会2014年学术交流会议 | 被引量 : 0次 | 上传用户:mzt1989
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  代谢性/退行性疾病(例如心脑血管疾病、癌症、糖尿病和老年痴呆症等)已经成为当今影响人群健康和生活质量、进而严重影响社会经济发展的重大问题。本文首次提出了关于代谢性疾病机制的一种应激耐受假设:当人体因年龄或其他因素,某些关键功能下降时,机体发生某种适应性改变——即通过某种功能的代偿性提高而抵消关键功能的下降,而不是通过启动相关修复机制回复这些关键功能,从而导致了一种应激耐受状态。代谢性是这种代偿-耐受性循环的结果。根据细胞应激响应的分子机制,本文提出通过自由基和金属离子可以调节应激耐受,启动组织的修复作用并加强其他药物的药理作用信号。
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