【摘 要】
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Objective Paeoniflorin (PF) is the major bioactivity of peony root which has been used to treat depressive patients in Traditional Chinese Medicine.However,
【机 构】
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Department of Neurobiology, Southern Medical University, Guangzhou 510515, China
【出 处】
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中国神经科学学会第四次会员代表大会暨第七届全国学术会议(The 7th Biennial Meeting and the
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Objective Paeoniflorin (PF) is the major bioactivity of peony root which has been used to treat depressive patients in Traditional Chinese Medicine.However,whether PF has antidepressant effect and if so,what may be the underlying mechanism remain unclear.Methods Adult male,C57BL/6J mice and wistar rats were administered PF (0.25-1mg/kg,i.p.) for 7-14 days,and then tested in the forced swimming test (FST),novelty-suppressed feeding test (NSF) and chronic mild stress paradigm (CMS) to determine the antidepressant effects of PF.BrdU immunofluorecence studies were used to investigate the effects of PF on neurogenesis in adult hippocampus and ELISA was used to quantify BDNF and VEGF levels.Results PF produced antidepressant actions in various models,including the FST,the NSF and the CMS.
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