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It is very challenging to high-throughput while sensitively and specifically detect bio-interesting molecules in biological fluids for studies of critical biological processes and uses in clinical diagnosis,drug discovery and food safety.Design and fabrication of controlled sensing film structures in nanoscales can be used to construct highly sensitive and superior specific biosensors and biochips.As demonstrations,free-standing biomimetic RGD-peptide-graphene film,carbonized TiO2 nanotubes-Hb structure and HRP-Au NPs-PANi NWs platform are constructed in nanoscales to sensitively in situ detect nitric oxide,peroxide sensor and ischemic cells,respectively.Highly sensitive labelless SPR chips are created for diagnosis purposes.In addition,single cell analysis in nanoscales has been developed by unique optoelectronic nanoprobe to achieve high temporal resolution for dynamic single cell analysis.In addition to our low cost lab-on-a chip devices,3rd generation of microfluidics will be presented.