Data analysis represents a key challenge for untargeted metabolomics studies and it commonly requires extensive processing of more than thousands of metabolite peaks included in raw high-resolution MS
蓝细菌光合系统通过铁氧还蛋白：NADP氧化还原酶(FNR)将还原力特异性地传递给NADP,产生NADPH用于推动CO2固定和其他生命过程。蓝细菌胞内的高NADPH/NADH比率限制了外源代谢途径在蓝细菌中的应用。改变FNR的辅因子特异性,使光合系统还原力合理分配,调整NADPH/NADH比率,将有助于提高光合作用效率和设计先进的光自养生物系统生产生物燃料分子和化学品。我们开发了一种偶联NAD(P)
神经管畸形(Neural tube defects,NTDs)是出生缺陷中发病率和死亡率最高的疾病,通常在0.6‰以下.中国是个人口大国,NTDs患者人群庞大,尤以山西省发生率最高,发生率已高达3.15‰,甚至个别地区已达到20‰,严重影响人口质量,也给社会医疗带来沉重压力.叶酸代谢障碍与NTDs以及神经系统严重畸形有关已被报道,叶酸通过甲基四氢叶酸,为S-腺苷蛋氨酸代谢提供甲基(SAM),SAM
MiR-181 family plays an important role in the regulation of various cellular functions.However,whether MiR-181b-5p mediates hepatic insulin resistance remains unknown.In this study,we found that miR-1
Extensive researches have suggested that miR-7 plays a critical role in cancer progression.However,the biological function of miR-7 in the pancreatic cancer(PC)progression is poorly understood.Therefo
neural tube defects,is a kind of serious congenital birth defects in the central Nervous system disease and is one of the major causes of perinatal fetal death and one of the major causes of the fetal
Nitidine chloride(NC)exhibits tumor suppressive function in a variety of human cancer types.However,the molecular mechanism of NC-triggered anti-cancer activity has not yet been completely elucidated.
for estrogen receptor(ER)positive breast cancer.Previous studies have demonstrated that mTORC1 and mTORC2 siganling acted as strong activators in breast cancer cells.However,the mechanisms how AA regu
苦蘵是一种含有多种活性成分的一年生草本植物。大量研究表明，苦蘵中的酸浆苦味素类物质(Physalins)具有抗肿瘤活性，具有很好的应用前景。但是，关于苦蘵次生代谢的研究尚且不多，可得信息也极为有限。我们首先建立了苦蘵毛状根培养体系，并以此为基础，研究茉莉酸甲酯(MeJA)对苦蘵酸浆苦味素类化合物的调控作用。利用代谢组及靶向质谱分析等技术手段，我们发现physalin D和H受到MeJA的显著诱导。
血系统肿瘤中,信号传导与转录激活因子3(Signal transducer and activator of transcription 3,STAT3)通路活化后致瘤作用已在多发性骨髓瘤、霍奇金淋巴瘤中多有报道。在DLBCL中,有实验证实STAT3活化主要存在于ABC亚型中,STAT3活化后导致下游与细胞增殖、凋亡相关基因的异常表达。