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  5. Self-Emulsified Drug Delivery System of Miconazole for Improved Oral Bioavailability

Self-Emulsified Drug Delivery System of Miconazole for Improved Oral Bioavailability

来源 :International Conference on Nanoscience & Technology,China 2 | 被引量 : 0次 | 上传用户：flash_chen
【摘 要】
：
Miconazole is a broad spectrum topical azole antifungal agent.The drug has poor water solubility and gastrointestinal permeability.Recently, miconazole has been shown to cause cancer cell apoptosis an
【作 者】
：
Jason Caballero Dong Liang 
【机 构】
：
Food and Drug Administration,Iowa,USA Department
【出 处】
：
International Conference on Nanoscience & Technology,China 2
【发表日期】
：
2013年3期
【关键词】
：
Miconazole Pharmacokinetics SEDDS LC-MS/MS 
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　　Miconazole is a broad spectrum topical azole antifungal agent.The drug has poor water solubility and gastrointestinal permeability.Recently, miconazole has been shown to cause cancer cell apoptosis and provide an alternative to treat systemic fungal infections.The objective of this study was to improve the oral bioavailability of miconazole for potential systemic application by developing self-emulsified drug delivery system (SEDDS).
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