论文部分内容阅读
Bone-marrow transplantation (BMT) can repopulate the liver through BM-derived hepatocyte (BMDH) generation, although the underlying mechanism remains unclear.Using fumarylacetoacetate hydrolase-deficient (Fah-/-) mice as a liver-failure model, we confirmed that BMDHs were generated by fusion of BM-derived CDI lb+F4/80+ myelomonocytes with resident Fah-/-hepatocytes.Hepatic NK cells became activated during BMDH generation and were the major IFN-γ producers.