【摘 要】
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Objectives: Dysfunctional Dopamine D2 Receptor (DRD2) may play a role in the pathophysiology of TS.This study aimed to explore the role of Dopamine D2 Receptor (DRD2) in an IDPN mouse model of TD by M
【机 构】
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Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine
【出 处】
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第二十次全国儿科中西医结合学术会议
论文部分内容阅读
Objectives: Dysfunctional Dopamine D2 Receptor (DRD2) may play a role in the pathophysiology of TS.This study aimed to explore the role of Dopamine D2 Receptor (DRD2) in an IDPN mouse model of TD by Micro-PET/CT, Real-Time PCR and Western blotting Methods: SD male rats were randomly divided into control (CG) and experimental (EG) groups (n=6).We simultaneously measured the density and brain distribution of dopamine D2 receptors (D2-Rs) by Micro-PE andWestern blotting;in addition, mRNA expression of D2-Rs was assessed by real time RT-PCR.Finally, glucose metabolism was evaluated in both groups.Results: The expression of dopamine D2-1ike receptor D2 (DRD2) in the striatum was significantly decreased both at the mRNA and protein levels.These findings were confirmed by the Micro-PET imaging.In addition, cerebral glucose metabolism was increased in IDPN mice compared with the control group (CG).Conclusions:These findings indicate that decreased DRD2 expression in the striatum may be involved in the pathogenesis of Tourette syndrome.
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