DNA origami directed in-situ combination of chemotherapy and gene therapy with enhanced antitumor ef

来源 :中国化学会第十届全国化学生物学学术会议 | 被引量 : 0次 | 上传用户:lvyuxuan3652008
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  Malignant tumor is one of the most serious diseases that affect human health.As patients with long-term chemotherapy,multidrug resistance of tumor is the most prominent problem.
其他文献
Chirality is one of the fundamental biochemical properties in the living world.Such as the transmembrane transport of drugs,most of drugs are actively transported into cells with the help of carrier p
环糊精(cyclodextrin,简称CD)是由6,7 或8 个D-吡喃葡萄糖单元通过α-1,4 糖苷键连接而成的腔内疏水、腔外亲水的环状低聚糖,分别称为α-,β-和γ-CD.环糊精及其衍生物是一类优秀的药物包合材料.
Lipid rafts play vital roles in cell mechanical stability that contributes to cancer metastasis rate,considered as promising membrane targets for cancer therapy.
Controlling the dynamic self-assembly of chiral amino acid droplets is a difficult task.To overcome the intrinsic challenges,we designed a host–guest system on the surface of a biomimetic membrane to
Chirality plays important roles in life systems that are essential to many natural processes.
G-quadruplex/hemin DNAzymes have been the focus of an intense interest recently owing to their quite unique enzyme-mimicking properties,but limited by its much lower catalytic activity than that of pr
酶活力在生物体内受到严格的反馈循环调控。受自然启发,人工设计可开关催化剂来精确控制生化反应吸引了科学家们的广泛兴趣。刺激响应型基团如偶氮苯、螺吡喃等都已被引入到智能催化剂的开发中来[1],而超分子体系以其较好的可逆性和刺激响应特性近年来成为重要的研究工具,例如Leigh等利用轮烷系统构建了多个调控催化系统[2],Brunsvele等利用CB[8]的主客体复合作用构建可开关调控的荧火素酶[3]。
Chiral environment widely consist in the life system,as has been the case for the basic components in the body of an organism,like sugar,fat,protein,nucleic acid and so on.
Dendrimer-like DNA nanostructures have attractive properties such as mechanical stability,highly branched nanostructure,customized sizes,and biocompatibility.
We herein demonstrate that DNA origami can work as a multifunctional platform integrating chemotherapeutic drug(doxorubicin),gold nanorods and tumour-specific aptamer MUC-1,to realize the effective ci