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  5. Separation of 2-heptamine by capillary electrophoresis used cyclodextrin chiral selector as additive

Separation of 2-heptamine by capillary electrophoresis used cyclodextrin chiral selector as additive

来源 :DaLian Internationall Symposia and Exhibition on Chromatogra | 被引量 : 0次 | 上传用户：norn1
【摘 要】
：
2-HPA is a new drug to cure the Parkinsons disease and only the R-isomer has the pharmacological activity.In order to separate 2-HPA we have tried many methods and found that capillary electrophoresis
【作 者】
：
Dairongji Yanglin Liu wei Deng yulin Meng weiwei 
【机 构】
：
School of Life Science and Technology, Beijing Institute of Technology, Beijing 100081, China
【出 处】
：
DaLian Internationall Symposia and Exhibition on Chromatogra
【发表日期】
：
2007年12期
【关键词】
：
Dansylchloride Chiral separation Capillary electrophoresis 2-HPA 
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　　2-HPA is a new drug to cure the Parkinsons disease and only the R-isomer has the pharmacological activity.In order to separate 2-HPA we have tried many methods and found that capillary electrophoresis was an efficient way.Further more, the precursor 2-HA and outgrowth 2-HPPA were also separated.Because there are not ultraviolet absorbing groups in 2-HPA and 2-HA, dansyl chloride was chosen to derivatize 2-HPA and 2-HA.2-HPPA was separated directly.
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