【摘 要】
：
In the 1950ties the team of Birger Blomb(a)ck purified fibrinogen and then characterized the two fibrinopeptides A (FPA) and B (FPB) released from the N-terminal part of fibrinogen by thrombin cleavag
【机 构】
：
Department of Molecular Medicine & Surgery Karolinska Institutet Karolinska University Hospital Swed
【出 处】
：
BITs 2rd Annual World Cancer Congress of Cardiology-2010(201
论文部分内容阅读
In the 1950ties the team of Birger Blomb(a)ck purified fibrinogen and then characterized the two fibrinopeptides A (FPA) and B (FPB) released from the N-terminal part of fibrinogen by thrombin cleavage.Theamino acid sequence of the peptides were analyzed from many different species and were used to trace evolutionary patterns.The sequence of the FPA nonapeptide was well preserved and led to the idea that it should be possible to inhibit thrombin by peptides imitating the area around the cleavage site.
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