寄生蠕虫胰岛素受体的研究进展

来源 :中国畜牧兽医学会兽医寄生虫学分会第十三次学术研讨会 | 被引量 : 0次 | 上传用户:Hai123321
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  胰岛素受体家族是一类重要的受体酪氨酸激酶(RTKs)。作为起始胰岛素信号传导的第一步,胰岛素(insulin)与胰岛素样生长因子-1(IGF-1)作为配体分别结合至胰岛素受体(IR)与胰岛素样生长因子受体(IGF-1R)的胞外区(ectodomain)并激活细胞膜内酪氨酸激酶活性,在生物体内发挥重要的生理功能。本文概述了胰岛素受体家族(IR和IGF-1R)的结构与功能,并介绍了胰岛素受体家族在寄生蠕虫方面的研究概况。
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