【摘 要】
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Our lab initiated the "Cancer Targeting Gene-Viro-Therapy (CTGVT)" strategy in 1999-2001 by inserting an antitumor gene into an oncolytic virus (OV), which
【机 构】
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XinYuanInstituteofMedicineandBiotechnologyCollegeofLifeScienceZhejiangSci-TechUniversityChina
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Our lab initiated the "Cancer Targeting Gene-Viro-Therapy (CTGVT)" strategy in 1999-2001 by inserting an antitumor gene into an oncolytic virus (OV), which also, therefore, named Gene Armed Oncolytic Virus Therapy (GAOVT), briefly it is OV-gene, an oncolytic virus harboring antitumor gene.The CTGVT (GAOVT) has much better antitumor effect than that of either respective gene therapy alone or oncolytic virus therapy alone.This is because that the OV can be replicated several hundred folds and the inserted gene can also be replicated at the same magnitutes, therefore, the antitumor effect of CTGVT was much increased.For example, the antitumor effect of our first CTGVT product ZD55-IL-24 (ZD55 is an OV from adenovirus) is much better than that of the gene therapy product Ad-IL-24, which is in phaseⅢ clinical trial in USA.
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