macrophage polarizationMacrophages participate in innate immune responses through different activation patterns,resulting in inflammatory reactions, tissue repairs, and other different biological effects.In preliminary studies using tumor models, we found that activating Notch signalingpromotes M1 polarization, while blocking Notch signaling promotes M2 polarization, suggestingthat Notch signaling is an important factor in the regulation of macrophage activation.microRNAs (miRNAs) are highly conversed, small non-coding RNA molecules thatplay an essential role in the regulation of gene expression and functions.