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Background: Toll-like receptor-7 (TLR7),which recognizes viral single-stranded RNA,can trigger immune complex glomerulonephritis in experimental lupus erythematosus.However,whether it modulates dendritic cells (DCs) phenotype and regulatory T cells (Treg) function is incompletely under stood.Method: Splenocytes and bone marrow DCs were obtained from 5-and 20-week-old female MRL 1pr/1pr mice and C57BL/6 mice.In addition,to understand the response of Treg and DCs to TLR7 ligation in vivo,16-week-old female MRL 1pr/1pr and C57BL/6 mice were distributed into two groups with or without intraperitoneal injections of TLR7 ligand ev-ery other day.