Advances and popularization of recombinant DNA technology have produced promising therapeutic protein candidates.However,the effectiveness of proteins has been limited by lack of efficient methods and tools to achieve intracellular protein delivery and poor stability of the delivered proteins.PTDs,also known as cell penetration peptides (CPPs),are short sequence cationic peptides that efficiently transduce the cell membrane with various cargos such as proteins,genes and particles [1].Most of efficient PTDs are composed of positive-charged amino acids such as arginine and lysine [2].Previously,we have reported high transduction efficiencies of oligo-arginine such as 9-met arginine [3].