论文部分内容阅读
OBJECTIVE The present study was aimed to evaluate whether the interindividual variation of cyclosporine dosages and blood concentration were associated with CYP3A4 and CYP3A5 polymorphism in renal transplant recipients.METHODS Two hundred and twenty-one renal transplant recipients treated with cyclosporine were genotyped for CYP3A4 rs4646437C>T and CYP3A5 6986G>A using ligase detection reations.Investigated the effects of genetic polymorphisms of CYP3A4 and CYP3A5 on cyclosporine dose adjusted trough concentration (C0/D) and 2 hours postdose concentration (C2/D) during the under 6 month period, 6 to 24 month period and exceed 24 month period after renal transplant.RESULTS CYP3A5 6986G>A genotype affect C0/D during under 6 month period, 6 to 24 month period, exceed 24 month period, P<0.05.C0/D: CYP3A5 6986GG>GA>AA.CYP3A4 rs4646437C>T and CYP3A5 6986G>A genotype affect C2/D during exceed 24 month period, P<0.05.C2/D: CYP3A4 rs4646437 CC>CT>TT, CYP3A5 6986GG>GA>AA.CONCLUSION CYP3A5 6986G>A genotype affect cyclosorine C0/D and C2/D.CYP3A4 rs4646437 C>T genotype affect cyclosorine C2/D.The effects of genotypes are varied in different stages.