PI3Kα相关论文
Phosphoinositide 3-kinases(PI3Ks) are lipid kinases which have been found in many cellular processes,including glucose h......
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Discovery of chromeno[4,3-c]pyrazol-4(2H)-one containing carbonyl or oxime derivatives as potential,
A series of novel chromeno[4,3-c]pyrazol-4(2H)-one containing carbonyl or oxime derivatives(4a-4n,5a-5n)have been synthe......
Simultaneous inhibition of PI3Kα and CDK4/6 synergistically suppresses KRAS-mutated non-small cell l
Objective:Activating KRAS mutations are the most common drivers in the development of non-small cell lung cancer (NSCLC)......
采用自组织分子场分析（SOMFA）构建了39个双吗啉类磷脂酰肌醇-3激酶仪（P13Ka）抑制剂的三维定量构效关系模型。交叉验证相关系数（q2）、非交......
恶性肿瘤正成为威胁人类健康的头号疾病。临床应用的直接作用于细胞有丝分裂或DNA合成修复等过程的传统抗肿瘤药物往往存在疗效不......
恶性肿瘤正成为威胁人类健康的第二大疾病。传统的抗肿瘤药物直接作用于细胞有丝分裂或DNA合成修复等过程,但往往存在疗效不佳、毒......
目的探讨PI3Kα抑制剂BYL719对人脐静脉血管内皮细胞(human umbilical vein endothelial cells,HUVEC)增殖与血管生成的影响。方法......
