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Discovery of an orally active VHL-recruiting PROTAC that achieves robust HMGCR degradation and poten
[期刊论文] 作者：Guoshun Luo,Zhenbang Li,Xin Lin,Xinyu Li,Yu Chen,Kun Xi,Maoxu Xiao,Hanlin Wei,Lizhe Zhu,Hua Xiang,
来源：药学学报：英文版 年份：2021
HMG-CoA reductase(HMGCR) protein is usually upregulated after statin(HMGCR inhibitor) treatment, which inevitably diminishes its therapeutic efficacy, provoking the need for higher doses associated with adverse effects. The proteolysis targ......
HMGB1 Modulated Lewis Cells Autophagy and Allowed Cells Survival by Positive Feedback via RAGE-HMGB1
[会议论文] 作者：Pan Zhang,Ping Ni,Ting Wang,Xin Lin,Yueqin Liu,Tingjun Bao,Chanjuan Xie,Wenlin Xu,Huaxi Xu,Zhaoliang,
来源：中国免疫学会第九届全国免疫学学术大会 年份：2014
Autophagy is a self-digesting mechanism responsible for the removal of long-lived proteins and damaged organelles by the lysosome or for allowing cells to survive during nutrient depletion and/or in t...
Proinflammatory Protein CARD9 Is Essential for Infiltration of Monocytic Fibroblast Precursors and C
[会议论文] 作者：Jingyuan Ren,Jie Du,Min Yang,Guanming Qi,Jiao Zheng,Lixin Jia,Jizhong Cheng,Cui Tian,Huihua Li,Xin Lin,
来源：第七届北京五洲心血管病研讨会 年份：2013
Background Angiotensin Ⅱ (Ang Ⅱ)-induced cardiac remodeling with the underlying mechanisms involving inflammation and fibrosis has been well documented.Cytosolic adaptor caspase recruitment domain 9 (...
[期刊论文] 作者：Shi-Nan Nie,Xiao-Ming Qian,Xue-Hao Wu,Shi-Yu Yang,Wen-Jie Tang,Bao-Hua Xu,Fang Huang,Xin Lin,Dong-Yan,
来源：城市道桥与防洪 年份：2003
该文从挂篮荷载计算、施工流程、支座及临时固结施工、挂篮安装及试验、合拢段施工、模板制作安装、钢筋安装、混凝土的浇筑及养生、测量监控等方面人手,介绍了S226海滨大桥...
[会议论文] 作者：Xuefeng Hu,Hao-Hueng Chang,Xiuqing Dong,Xin Lin,Yingnan Song,Bingmei Wang,Chengling Lin,Jyh-Wei Lee,YiPing,
来源：中国细胞生物学学会2015年全国学术大会 年份：2015
BACKGROUND:Stem cell-base reconstitution of bioengineered teeth requires mesenchyme-and epithelium-derived stem cells.Dental mesenchyme-derived stem cells h...
,TMEM43-S358L mutation enhances NF-κB-TGFβ signal cascade in arrhythmogenic right ventricular dyspla
[期刊论文] 作者：Jiang,Yulin Li,Dandan Yang,Youcai Ma,Bing Zhang,Xuan Li,Pei Zhang,Xiaoyu Hu,Xueqiang Zhao,Jie Du,Xin Lin,
来源：蛋白质与细胞 年份：2019
Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVDIC) is a genetic cardiac muscle disease that accounts for approximately 30％ sudden cardiac death i...
Studying bona fide SARS-CoV-2 biology in a BSL-2 biosafety environment using a split-virus-genome sy
[期刊论文] 作者：Yingxin Ma,Guobin Mao,Weishan Yang,Guoqiang Wu,Guoqiang Li,Xiaoying Li,Xin Lin,Junnan Lu,Shijun Zhao,,
来源：Science China(Life Sciences) 年份：2022
＜正＞Dear Editor,Severe acute respiratory syndrome coronavirus 2（SARSCoV-2） was identified as the pathogen causing the coronavirus disease（COVID-19）, which sometimes resulted in fatal pneumonia（Hu et al...
A Genetic Susceptibility Study of Lung Cancer Risk Potentially Associated with Polycyclic Aromatic H
[期刊论文] 作者：LIN Nan,MU Xin Lin,WANG Gui Lian,REN Yu Ang,TANG De Liang,WANG Bin,LI Zhi Wen,SU Shu,KAN Hai Dong,TAO,
来源：Biomedical and Environmental Sciences 年份：2017
To establish a genetic susceptibility assessment model of lung cancer risk potentially associated with polycyclic aromatic hydrocarbon(PAH) inhalation exposure...
Bioelectrical Impedance Phase Angle as a Predictors of Mortality in Patients with Lung Cancer: a Pro
[期刊论文] 作者：Jing Guo,Fei Fei Chong,Liang Yu Yin,Xin Lin,Meng Yuan Zhang,Mu Li Shi,Hong Mei Zhang,Jie Liu,Hong Xia,
来源：肿瘤营养学杂志（英文） 年份：2022
Objective Bioelectrical impedance analysis (BIA) is used to measure a patient\'s body composition. The phase angle (PA), the major parameter in BIA, is one of the most sensitive indicators of malnutrition. The aim of the current study was t......
[期刊论文] 作者：Genfan DING,Qingquan YANG,Guosheng XU,Xin LIN,Yang YE,Ran CHEN,Yumin WANG,Qing ZANG,Heng LAN,Liang CHEN,
来源：等离子体科学和技术（英文版） 年份：2021
The properties of grassy edge-localized modes (ELMs) in EAST in the favorable and unfavorable Bt are statistically studied.Statistical analysis indicates that there is no systematical difference in the frequencies of grassy ELMs under the t......
Maternal Perfluorinated Compound Exposure and Risk of Early Pregnancy Loss: A Nested Case-control St
[期刊论文] 作者：MI Xin,LIN Shi Qi,ZHANG Xiao Fen,LI Jia Jia,PEI Li Jun,JIN Feng,LIAO Qi,XIE Li Min,WEI Li Cong,HAO Chan,
来源：生物医学与环境科学（英文版） 年份：2022
Early pregnancy loss, defined as a nonviable intrauterine pregnancy occurring before 12 weeks of gestation, is estimated to affect 25％ of clinically diagnosed pregnancies[1]. Several demographic, lifestyle, and environmental risk factors hav......
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