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[会议论文] 作者：Xinyong Liu,
来源：2015年全国药物化学学术会议暨第五届中英药物化学学术会议 年份：2015
Guided by crystal structures of HIV-1 RT/diarylpyrimidine(DAPY)complex,molecular modeling studies and our previous efforts,series of novel DAPY derivatives were rationally designed,synthesized,and eva...
[会议论文] 作者：Xinyong Liu,
来源：2015年全国药物化学学术会议暨第五届中英药物化学学术会议 年份：2015
Guided by crystal structures of HIV-1 RT/DAPY complex,molecular modeling studies and our previous efforts,series of novel DAPY derivates were rationally designed,synthesized,and evaluated for their an...
Design,Synthesis of Novel Substituted Heterothiadiazines and Heterothiatriazines as Potent HIV-1 NNR
[会议论文] 作者：Dr Xinyong Liu,
来源：2006中国天津世界艾滋病日科技会议 年份：2006
The HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) are structurally diverse compounds that act by binding to an allosteric site,approximately 10A from the polymerase active site,causin...
Design,synthesis and evaluation of novel piperazin-1-yl(thiazol-4-yl)methanone derivatives as factor
[会议论文] 作者：Hongfei Chen,Xinyong Liu,
来源：全国药物化学学术会议暨第四届中英药物化学学术会议 年份：2013
...
[会议论文] 作者：Jun Wang,Xinyong Liu,
来源：第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会 年份：2012
HIV-1 non-nucleoside reverse transcriptase inhibitors(NNRTIs) play important role in the currently clinical AIDS therapies because of their potency and specificity.However,the efficacy of NNRTIs is se...
[会议论文] 作者：Jiapei YANG,Peng ZHAN,Xinyong LIU,
来源：2015年全国药物化学学术会议暨第五届中英药物化学学术会议 年份：2015
A series of novel 6-substituted diarylpyridine derivatives targeting the entrance channel of the NNRTI binding pocket(NNIBP)of HIV-1 RT was designed through a molecular hybridization strategy....
Discovery of Novel Diarylpyrimidines as Potent HIV NNRTIs via A Structure-guided Core-refining Appro
[会议论文] 作者：Xiao Li,Peng Zhan,Xinyong Liu,
来源：全国药物化学学术会议暨第四届中英药物化学学术会议 年份：2013
Guided by crystal structures of HIV-1 RT/DAPY complex and molecular modeling studies,a series of novel DAPY derivatives were rationally designed,synthesized and evaluated for their anti-HIV activities...
[期刊论文] 作者：LI Xiaofan,SHEN Xinyong,LIU Ji,
来源：大气科学进展：英文版 年份：2014
对加倍的大气的二氧化碳集中的降雨回答通过二个二维的解决云的模型敏感实验的分析被调查。一个个实验模仿了夏天前在在夏至附近的南部的中国上的重降雨，而其它个实验在冬至附...
[会议论文] 作者：Xiao Li,Peng Zhan,Xinyong Liu,
来源：2015年全国药物化学学术会议暨第五届中英药物化学学术会议 年份：2015
In continuation of our efforts toward the discovery of potent HIV-1 NNRTIs with novel structures,a series of novel imidazopyridinylthioacetanilide derivatives were rationally designed via scaffold hop...
First Discovery of Novel 3-Hydroxy-quinazoline-2,4(1H,3H)-diones as Specific Anti-Vaccinia and Adeno
[会议论文] 作者：Dongwei Kang,Peng Zhan,Xinyong Liu,
来源：中国化学会第30届学术年会 年份：2016
The construction of a novel series of 1,2,3-triazolyl 3-hydroxy-quinazoline-2,4(1H,3H)-diones utilizing Cu(I)-catalyzed azide-alkyne 1,3-dipolar cycloadditi...
[会议论文] 作者：BOSHI HUANG,PENG ZHAN,XINYONG LIU,
来源：2015年全国药物化学学术会议暨第五届中英药物化学学术会议 年份：2015
In continuation of our efforts to develop new,potent,low cytotoxic anti-HIV agents [1],a series of novel 2-(pyridin-3-yloxy)acetamide derivatives were designed derived from the privileged structures o...
Design,Synthesis and Evaluation of Novel Trimethylpyrazine-2-carbonyloxy-cinnamic Acid Esters as Pot
[会议论文] 作者：Hongfei Chen,Peng Zhan,Xinyong Liu,
来源：第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会 年份：2012
Ligustrazine(tetramethyl pyrazine,TMP,a major effective component of Chinese traditional herbal medicine Chuanxiong,has been reported to be a multifunctional drug in the treatment of cardiovascular di...
Effects of Doubled Carbon Dioxide on Rainfall Responses to Large-Scale Forcing: A Two-Dimensional Cl
[期刊论文] 作者：LI Xiaofan,SHEN Xinyong,LIU Jia,
来源：黑龙江科技信息 年份：2014
本文通过对荣华二采区10...
Torrential Rainfall Responses to Ice Microphysical Processes during Pre-Summer Heavy Rainfall over S
[期刊论文] 作者：SHEN Xinyong,LIU Jia,Xiaofan LI,
来源：大气科学进展（英文版） 年份：2012
In this study,the effects of key ice microphysical processes on the pre-summer heavy rainfall over south China during 3-8 June 2008 were investigated.A series o...
First Discovery of Novel 3-Hydroxy-quinazoline-2,4(1H,3H)-diones as Specific Anti-Vaccinia and Adeno
[会议论文] 作者：Dongwei Kang,Peng Zhan,Xinyong Liu,
来源：中国化学会第30届学术年会 年份：2016
The construction of a novel series of 1,2,3-triazolyl 3-hydroxy-quinazoline-2,4(1H,3H)-diones utilizing Cu(I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition(CuAAC)is described....
Discovery of Novel Diarylpyrimidines as Potent HIV NNRTIs via A Structure-guided Core-refining Appro
[会议论文] 作者：Xiao Li,Peng Zhan,Xinyong Liu,
来源：全国药物化学学术会议暨第四届中英药物化学学术会议 年份：2013
Guided by crystal structures of HIV-1 RT/DAPY complex and molecular modeling studies,a series of novel DAPY derivatives were rationally designed,synthesized...
Design,synthesis and bioactivity of novel N-arylmethyl substituted piperidine-linked aniline derivat
[会议论文] 作者：Lingzi Zhang,Peng Zhan,Xinyong Liu,
来源：全国药物化学学术会议暨第四届中英药物化学学术会议 年份：2013
Investigations focused on the resistance profiles of NNRTIs for almost two decades gave rise to the discovery and development of diarylpyrimidine(DAPY)derivatives,such as the clinically approved drugs...
[会议论文] 作者：Wenmin Chen,Peng Zhan,Xinyong Liu,
来源：第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会 年份：2012
Recently,3-iodo-4-phenoxypyridinone derivatives (IOPYs) were identified as a novel class of highly potent non-nucleoside reverse transcriptase inhibitors (NNRTIs) with superior activity against both w...
[期刊论文] 作者：Xinyong Shen,Jia Liu,Xiaofan L,
来源：大气科学进展：英文版 年份：2012
In this study,the effects of key ice microphysical processes on the pre-summer heavy rainfall over southern China during 3-8 June 2008 were investigated.A serie...
Design,synthesis and biological evaluation of novel fused heterocyclic derivatives as potent HIV-1 N
[会议论文] 作者：Dongwei KANG,Peng ZHAN,Xinyong LIU,
来源：2015年全国药物化学学术会议暨第五届中英药物化学学术会议 年份：2015
In current anti-HIV drug research field,diarylpyrimidines(DAPYs)represents the most potent and promising NNRTIs class for its excellent pharmacological profiles.Etravirine and rilpivirine,two most rep...
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