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Pharmacological and Structural Diversity of Voltage-gated Sodium Channels Traced by Scorpion Neuroto
[会议论文] 作者：Yong-Hua Ji,
来源：The 3rd Ion Channel Conference: Ion channels-Structure, Func 年份：2011
Voltage-gated sodium channels (VGSCs) are pivatol transmembrane proteins responsible for initiating and conducting action potentials in excitable cells.Dive...
Approaching the channelopathies associated with epilepsy by natural sodium channel-specific modulato
[会议论文] 作者：Yong-Hua JI,
来源：中国神经科学学会第九届全国学术会议暨第五届会员代表大会 年份：2011
Voltage-gated sodium channel plays an indispensable role in the initiation and propagation of the action potential.Alterations of sodium channel properities are associated with several neurological pa...
,Exploring the obscure profiles of pharmacological binding sites on voltage-gated sodium channels by
[期刊论文] 作者：Zhi-Rui Liu,Pin Ye,Yong-Hua Ji,
来源：蛋白质与细胞 年份：2011
Diverse subtypes of voltage-gated sodium channels (VGSCs) have been found throughout tissues of the brain,muscles and the heart.Neurotoxins extracted from the v...
[会议论文] 作者：Jie Tao,Jian Shi,Yong-hua Ji,
来源：第12届生物毒素研究及医药应用学术大会 年份：2015
The large-conductance calcium-activated potassium (BK) channels distributed in both excitable and non-excitable cells are key participants in a variety of physiological functions.Martentoxin (MarTX),...
BmK I directly activates Nav1.8 in primary sensory neurons to induce neuronal hyperexcitability in r
[会议论文] 作者：Pin Ye,Li-Ming Hua,Yong-Hua Ji,
来源：第12届生物毒素研究及医药应用学术大会 年份：2015
Voltage-gated sodium channels (VGSCs) in primary sensory neurons play a key role in transmitting pain signals to the central nervous system.BmK I, a site-3 sodium channel-specific toxin from scorpion...
[期刊论文] 作者：Peng QIAO,Xiao-Pan ZUO,Zhi-Fang CHAI,Yong-Hua JI,
来源：生物化学与生物物理学报（英文版） 年份：2004
In present study the full-length cDNA of a novel toxin from the venom gland of spider ithoctonus huwena, named as SHT-I, has been cloned using the strategy of r...
[期刊论文] 作者：You Zhou,Fang-Hao Fang,Zhi-Rui Liu,Yong-Hua Ji,
来源：蛋白质与细胞 年份：2015
Dear Editor,Hair cells (HCs) clustered in cochlear sensory epithelia produce spontaneous spike and evoked action potentials during the developmental stage of au...
[会议论文] 作者：Pin YE,Xing-Hua FENG,Hong-Tian YANG,Yong-Hua JI,
来源：中国神经科学学会第九届全国学术会议暨第五届会员代表大会 年份：2011
Previously, domain Ⅳ S3/S4 linker was demonstrated to be an important region determing the sensitivity of sodium channels to BmK Ⅰ, a sodium channel-specific site-3 modulator.But the localization of m...
The Antinociceptive response of Buthus martensi Karsch (BmK) AS, a Na channel Receptor Site 4 Modula
[会议论文] 作者：JIN CHEN,XING-HUA FENG,JIAN SHI,YONG-HUA JI,ZHI-YONG TAN,
来源：Shanghai International Conference on Physiological(Shanghai 年份：2004
...
The Antinociceptive response of Buthus martensi Karsch (BmK) AS, a Na channel Receptor Site 4 Modula
[会议论文] 作者：JIN CHEN,XING-HUA FENG,JIAN SHI,ZHI-YONG TAN,YONG-HUA JI,
来源：Shanghai International Conference on Physiological(Shanghai 年份：2004
...
The pharmacological characterization of martentoxin on the BK channels subtype composed of and subun
[会议论文] 作者：Yan-Hong DUAN,Jian SHI,Ying CHEN,Fu-Xue CHEN,Yong-Hua JI,
来源：中国神经科学学会第四次会员代表大会暨第七届全国学术会议(The 7th Biennial Meeting and the 年份：2007
Martentoxin,a 37 residues peptide purified from the venom of Chinese scorpion Buthus martensi Karch (BmK),was capable of blocking large-conductance Ca2+-activated K+ (BK) channels in adrenal medulla c...
Rat pain-related responses induced by BmK I, a sodium channel modulator from scorpion Buthus martens
[会议论文] 作者：Zhan-Tao BAI,Tong LIU,Xue-Yan PANG,Zhi-Fang CHAI,Jian SHI,Yong-Hua JI,
来源：中国神经科学学会第四次会员代表大会暨第七届全国学术会议(The 7th Biennial Meeting and the 年份：2007
The experimental scorpion BmK (Buthus martensi Karsch) sting test has been demonstrated to be an available inflammatory animal pain model to understand the mechanisms of the tonic spontaneous response...
Characterization of neuronal death in a convulsant model of rats, induced by intrahippocampal inject
[会议论文] 作者：Jun YANG,Rong ZHAO,Chun-Chun WENG,Xu-Ying ZHANG,Jian-Wei ZHANG,Yong-Hua JI,
来源：中国神经科学学会第四次会员代表大会暨第七届全国学术会议(The 7th Biennial Meeting and the 年份：2007
BmK(I),an α-like neurotoxin acting on receptor-3 of the voltage-gated sodium channel,has been demonstrated to evoke epileptic seizures in rats.In the present study,we investigated the hippocampus morp...
Anticonvulsant effect of BmK IT2, a sodium channel-specific neurotoxin, in experimental epilepsy mod
[会议论文] 作者：Rong ZHAO,Xu-Ying ZHANG,Jun YANG,Chun-Chun WENG,Jian-Wei ZHANG,Yong-Hua JI,
来源：中国神经科学学会第四次会员代表大会暨第七届全国学术会议(The 7th Biennial Meeting and the 年份：2007
In the present study,the anticonvulsant effect of BmK IT2,a sodium channel-specific polypeptide purified from the venom of Chinese scorpion Buthus martensi Karsch,has been investigated in experimental...
[会议论文] 作者：Xue-Yan PANG,Tong LIU,Feng JIANG,Zhan-Tao BAI,Zhu-Fang CHAI,Yong-Hua JI,
来源：中国神经科学学会第四次会员代表大会暨第七届全国学术会议(The 7th Biennial Meeting and the 年份：2007
Scorpion Buthus martensi Karch (BmK) venom could induce severe ongoing pain,inflammation and burning sensation in human.In the present study,the extracellular signaling-regulated kinases (ERK) in spin...
Degranulation of mast cells and histamine release involved in pain-related behaviors and edema induc
[会议论文] 作者：Tong LIU,Zhan-Tao BAI,Xue-Yan PANG,Zhu-Fang CHAI,Feng JIANG,Yong-Hua JI,
来源：中国神经科学学会第四次会员代表大会暨第七届全国学术会议(The 7th Biennial Meeting and the 年份：2007
In the present study,the degranulafion of mast cell and histamine release involved in scorpion Buthus martensi Karch (BmK) venom induced-pain behaviors and edema was investigated.It was found that the...
[期刊论文] 作者：Zhi-Rui Liu,Jie Tao,Bang-Qian Dong,Gang Ding,Zhi-Jun Cheng,Hui-Qiong He,Yong-Hua Ji,
来源：神经科学通报（英文版） 年份：2012
...
Epigallocatechin-3-gallate induces apoptosis, inhibits proliferation and decreases invasion of gliom
[期刊论文] 作者：Hong Li,Zhe Li,Ya-Ming Xu,Yue Wu,Kang-Kang Yu,Can Zhang,Yong-Hua Ji,
来源：神经科学通报（英文版） 年份：2014
...
Activation of mammalian target of rapamycin contributes to pain nociception induced in rats by BmK I
[期刊论文] 作者：Feng Jiang,Li-Ming Hua,Yun-Lu Jiao,Pin Ye,Jin Fu,Zhi-Jun Cheng,Gang Ding,Yong-Hua Ji,,
来源：Neuroscience Bulletin 年份：2004
The mammalian target of rapamycin (mTOR) pathway is essential for maintenance of the sensitivity of certain adult sensory neurons. Here, we investigated whether...
[期刊论文] 作者：Guokun Zhou,Yunlu Jiao,You Zhou,Shichao Qin,Jie Tao,Feng Jiang,Zhi-Yong Tan,Yong-Hua Ji,
来源：神经科学通报（英文版） 年份：2018
Dear Editor,rnAs the key contributor to the rising phase of action potentials in dorsal root ganglion (DRG) neurons,voltagegated sodium channels (VGSCs) are important in physiological and pathological pain conditions.For instance,abnormal e......
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