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Discovery of New SIRT2 Inhibitors by Utilizing a Consensus DockingScoring Strategy and Structure-Act
[会议论文] 作者：Wang,Guo Zhang,Yanlin Wang,Xiaojuan Jiang,Qizheng Sun,Luyi Huang,Rong Xiang,Yiguo Hu,Linli Li,Shengyong Yang,
来源：第九届国际分子模拟与信息技术应用学术会议(ICMS&I2018) 年份：2018
SIRT2,which is a NAD+(nicotinamide adenine dinucleotide)dependent deacetylase,has been demonstrated to play an important role in the occurrence and developm...
Structures of signaling complexes of lipid receptors S1PR1 and S1PR5 reveal mechanisms of activation
[期刊论文] 作者：Yuan Yuan,Guowen Jia,Chao Wu,Wei Wang,Lin Cheng,Qian Li,Ziyan Li,Kaidong Luo,Shengyong Yang,Wei Yan,Zhaoming,
来源：细胞研究（英文版） 年份：2021
Sphingosine-1-phosphate (S1P) is an important bioactive lipid molecule in cell membrane metabolism and binds to G protein-coupled S1P receptors (S1PRs) to regulate embryonic development,physiological homeostasis,and pathogenic processes in ......
Structural insights into sphingosine-1-phosphate recognition and ligand selectivity of S1PR3-Gi sign
[期刊论文] 作者：Chang Zhao,Lin Cheng,Wei Wang,Heli Wang,Yongbo Luo,Yuying Feng,Xuehui Wang,Hong Fu,Ye Cai,Shengyong Yang,
来源：细胞研究（英文版） 年份：2022
Dear Editor,rnLipids are essential for all life on earth and play critical roles in energy storage and the formation of cellular membranes.Sphingosine-1-phosphate (S1P) is a naturally occurring bioactive lysophospholipid that regulates fund......
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