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Design,Synthesis and Structure-Activity Relationship Studies of 3-(Phenylethynyl)-1H-pyrazolo[3,4-d]
[会议论文] 作者：Chun-Hui Zhang,Ming-Wu Zheng,Ya-Ping Li,Xing-Dong Lin,Mei Huang,Lei Zhong,Guo-Bo Li,Rong-Jie Zhang,Wan-Ting,
来源：2015年全国药物化学学术会议暨第五届中英药物化学学术会议 年份：2015
Triple-negative breast cancer(TNBC)is one of the most aggressive and deadly subtypes of breast cancer.[1-3] So far,there is no small molecule targeted drugs...
From Lead to Drug CandidateOptimization of 3-(Phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine Der
[会议论文] 作者：Chun-Hui Zhang,Kai Chen,Yan Jiao,Lin-Li Li,Ya-Ping Li,Rong-Jie Zhang,Ming-Wu Zheng,Lei Zhong,Shen-Zhen,
来源：第九届国际分子模拟与信息技术应用学术会议(ICMS&I2018) 年份：2018
Herein we report the sophisticated process of structural optimization toward a previously disclosed Src inhibitor,compound 1,which showed high potency in th...
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