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[期刊论文] 作者:Michael Roggendorf,, 来源:World Journal of Gastroenterology 年份:2011
AIM: To investigate the expression of programmed death (PD)-1,PD ligand 1 (PD-L1) and PD-L2 in liver tissues in the context of chronic hepatitis and hepatocellu...
[期刊论文] 作者:Michael Roggendorf,, 来源:Virologica Sinica 年份:2012
The mitogen activated protein kinases-extracellular signal regulated kinases (MAPK-ERK) pathway is involved in regulation of multiple cellular processes includi...
[期刊论文] 作者:Joerg Timm Michael Roggendorf, 来源:世界胃肠病学杂志:英文版(电子版) 年份:2007
With approximately 3% of the world’s population (170 million people) infected with the hepatitis C virus (HCV), the WHO has declared HCV a global health proble...
[期刊论文] 作者:Joerg Timm,Michael Roggendorf,, 来源:World Journal of Gastroenterology 年份:2007
With approximately 3% of the world’s population (170 million people) infected with the hepatitis C virus (HCV), the WHO has declared HCV a global health proble...
[期刊论文] 作者:Ina Schulte,Michael Roggendorf,, 来源:Virologica Sinica 年份:2008
The woodchuck model is an excellent animal model to study hepadnaviral infection. The new progresses in this model made possible to examine the T-cell mediated...
[期刊论文] 作者:Jia Liu,Anna Kosinska,Mengji Lu,Michael Roggendorf,, 来源:Virologica Sinica 年份:2014
Chronic hepatitis B virus(CHB) is currently treated with either interferon-based or nucleot(s)idebased antiviral therapies.However,treatment with pegylated inte...
[会议论文] 作者:Michael Roggendorf,Anna Kosinska,Jia Liu,Mengji Lu, 来源:14th international symposium on viral hepatitis and liver di 年份:2012
[期刊论文] 作者:管世鹤,陆蒙吉,Michael Roggendorf,Joerg F.Schlaak, 来源:中华实验和临床病毒学杂志 年份:2005
为了解抗病毒核苷类似物拉米夫定(3TC)处理的Hep.2.15细胞干扰素(IFN)抗病毒基因表达谱以及3TC对IFN信号转导途径的影响而开展此项研究.具体方法:将培养的Hep2.2.15细胞用3TC处理,再以IFN-α刺激6 h,分离细胞总RNA,经逆转录、32P标记后与尼龙膜上的探针基因芯片......
[期刊论文] 作者:Hubert E.Blum,Michael Roggendorf,Ji-dong Jia,Meng-ji Lu,Dong-liang Yang, 来源:中国病毒学 年份:2008
Chronic viral hepatitis continues to be a major public health priblem and the most common cause of liver disease worldwide....
[会议论文] 作者:Anna Kosinska,Michael Roggendorf,Lena Johrden,Ejuan Zhang,Melanie Fiedler, 来源:14th international symposium on viral hepatitis and liver di 年份:2012
[期刊论文] 作者:管世鹤,杨东亮,陆蒙吉,Michael Roggendorf, 来源:中国感染与化疗杂志 年份:2006
目的了解α干扰素(interferom-α,IFN—α)诱导的抗病毒蛋白MxA和2′,5′-寡腺苷酸合成酶(2′-,5′-OAS)在人肝胚瘤细胞株HepG2和HBV稳定转染的HepG2.2.15细胞中的表达情况。方法将培...
[期刊论文] 作者:Petra Grnewald,Michael Roggendorf,Guido Gerken,Jrg F Schlaak,, 来源:World Journal of Gastroenterology 年份:2007
AIM: To characterize the IFN-response and its modul- ation by the antiviral compound lamivudine in HBV- transfected HepG2.2.15 cells. METHODS: HepG2.2.15 and He...
[期刊论文] 作者:管世鹤,杨东亮,陆蒙吉,Michael Roggendorf,Joerg F.Schlaak,, 来源:中国感染与化疗杂志 年份:2006
目的了解α干扰素(interferon-α,IFN-α)诱导的抗病毒蛋白MxA和2’,5’-寡腺苷酸合成酶(2’,5’-OAS)在人肝胚瘤细胞株HepG2和HBV稳定转染的HepG2.2.15细胞中的表达情况。方...
[期刊论文] 作者:Rongjuan Pei,Xiaoyong Zhang,Song Xu,Zhongji Meng,Michael Roggendorf,Mengji Lu,Xinwen Chen, 来源:中国病毒学 年份:2012
The mitogen activated protein kinases-extracellular signal regulated kinases (MAPK-ERK) pathway is involved in regulation of multiple cellular processes includi...
[会议论文] 作者:Zhongji Meng,Xiaoyong Zhang,Rongjuan Pei,Michael Roggendorf,Mengji Lu,Jun Wu,Dongliang Yang,Yang Xu, 来源:中华医学会第十六次全国病毒性肝炎及肝病学术会议 年份:2013
[期刊论文] 作者:管世鹤,刘华平,杨东亮,陆蒙吉,Michael Roggendorf,Joerg F.Schlaak, 来源:中华实验和临床病毒学杂志 年份:2005
目的 了解人肝胚瘤细胞株Hep G2和稳定转染HBV全基因组细胞株HepG2.2.15的干扰素(IFN)抗病毒基因表达谱.方法选择与IFN抗病毒及其信号转导途径相关的288个IMAGE克隆,经聚合酶链反应(PCR)扩增相应的基因片段,将扩增的DNA片段纯化后点样于阳离子尼龙膜上以制备成......
[期刊论文] 作者:Shi-He Guan,Mengji Lu,Petra Grünewald,Michael Roggendorf,Guido Gerken,J(o)rg F Schlaak, 来源:世界胃肠病学杂志(英文版) 年份:2007
AIM: To characterize the IFN-response and its modulation by the antiviral compound lamivudine in HBVtransfected HepG2.2.15 cells.METHODS: HepG2.2.15 and HepG2 c...
[会议论文] 作者:Zhongji Meng,Xiaoyong Zhang,Jun Wu,Rongjuan Pei,Yang Xu,Dongliang Yang,Michael Roggendorf,Mengji Lu, 来源:中华医学会第十六次全国病毒性肝炎及肝病学术会议 年份:2013
Background & Aims Our previous Conclusions showed that the knockdown of woodchuck hepatitis virus (WHV) by RNA interference (RNAi) led to upregulation of interferon stimulated genes (ISGs) in primary...
[期刊论文] 作者:管世鹤,刘华平,杨东亮,陆蒙吉,Michael Roggendorf,Joerg F.Schlaak, 来源:中华实验和临床病毒学杂志 年份:2005
目的 了解人肝胚瘤细胞株Hep G2和稳定转染HBV全基因组细胞株HepG2.2.15的干扰素(IFN)抗病毒基因表达谱。方法选择与IFN抗病毒及其信号转导途径相关的288个IMAGE克隆,经聚合酶链反应(PCR)扩增相应的基因片段,将扩增的DNA片段纯化后点样于阳离子尼龙膜上以制备成人工芯片......
[期刊论文] 作者:Wang,Jun-Jie Bao,Jun-Zhong Wang,Yang Wang,Min Jiang,Ming-You Xing,Wan-Guang Zhang,Jun-Ying Qi,Michael Roggendorf, 来源:世界胃肠病学杂志(英文版) 年份:2011
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