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Small molecule inhibitors of amyloid β peptide aggregation as a potential therapeutic strategy for A
[期刊论文] 作者：Qin NIE,Xiao-guang DU,Mei-yu GENG,
来源：中国药理学报（英文版） 年份：2011
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,Oligomannurarate sulfate inhibits CXCL12/SDF-1-mediated proliferation and invasion of human tumor c
[期刊论文] 作者：Wei-wei WEN,Shao XIE,Xian-liang XIN,Mei-yu GENG,Jian DING,Yi CHEN,
来源：中国药理学报（英文版） 年份：2013
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,Evaluation of in vitro and in vivo activity of a multityrosine kinase inhibitor, AL3810, against hu
[期刊论文] 作者：Qin XIE,Hui CHEN,Jing AI,Ying-lei GAO,Mei-yu GENG,Jian DING,Yi CHEN,
来源：中国药理学报（英文版） 年份：2017
Thyroid cancer is the most common type of endocrine neoplasia.Despite recent breakthroughs in treatment of the disease,the treatment of advanced,progressive thy...
Effects of dermatan sulfate derivatives on platelet surface P-selectin expression and protein C acti
[期刊论文] 作者：Sheng-Li Ji,Hai-Yan Du,Yan-Qing Chi,Hui-Fei Cui,Ji-Chao Cao,Mei-Yu Geng,Hua-Shi Guan,
来源：世界胃肠病学杂志（英文版） 年份：2004
AIM: To investigate the effect of dermatan sulfate (DS)derivatives on platelet surface P-selectin expression and blood activated protein C (APC) activity in pat...
Inhibitory effect of heparin-derived oligosaccharides on secretion of interleukin-4 and interleukin-
[期刊论文] 作者：Sheng-Li Ji,Hui-Fei Cui,Feng SHI,Yan-Qing Chi,Ji-Chao Cao,Mei-Yu Geng,Hua-Shi Guan,
来源：世界胃肠病学杂志（英文版） 年份：2004
AIM: To investigate the inhibitory effect of heparin-derived oligosaccharides (Oligs) on secretion of interleukin-4 (IL-4)and interleukin-5 (IL-5) from human pe...
[期刊论文] 作者：Jin QIAN,Cai-hua ZHU,Shuai TANG,Ai-jun SHEN,Jing AI,Jing LI,Mei-yu GENG,Jian DING,
来源：中国药理学报（英文版） 年份：2009
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Sulfated polymannuroguluronate inhibits Tat-induced SLK cell adhesion via a novel binding site, a KK
[期刊论文] 作者：Yan-lin WU,Jing AI,Jing-ming ZHAO,Bing XIONG,Xiao-jie XIN,Mei-yu GENG,Xian-liang XIN,Han-dong JIANG,
来源：中国药理学报（英文版） 年份：2011
...
[期刊论文] 作者：Jing ZHANG,Yi CHEN,Xian-liang XIN,Qiu-ning LI,Ming LI,U-ping LIN,Mei-yu GENG,Jian DING,
来源：中国药理学报（英文版） 年份：2010
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,GA3, a new gambogic acid derivative, exhibits potent antitumor activities in vitro via apoptosis-in
[期刊论文] 作者：Hua XIE,Yu-xin QIN,Yun-long ZHOU,Lin-jiang TONG,Li-ping LIN,Mei-yu GENG,Wen-hu DUAN,Jian DING,
来源：中国药理学报(英文版) 年份：2009
Aim: Gambogic acid (GA) is the major active ingredient of gamboge, which is secreted from a Chinese traditional medicine, Garcinia hanburyi, which possesses pot...
[期刊论文] 作者：Yue-hong Chen,Hao Lv,Ning Shen,Xiao-min Wang,Shuai Tang,Bing Xiong,Jian Ding,Mei-yu Geng,Min Huang,
来源：中国药理学报（英文版） 年份：2020
KRAS is one of the most important proto-oncogenes.Its mutations occur in almost all tumor types,and KRAS mutant cancer is still lack of effective therapy.Prenyl...
,Marine-derived oligosaccharide sulfate (JG3) suppresses heparanase-driven cell adhesion events in h
[期刊论文] 作者：Qiu-ning LI,Hai-ying LIU,Xian-liang XIN,Qiu-ming PAN,Lu WANG,ling ZHANG,Qin CHEN,Mei-yu GENG,Jian DING,
来源：中国药理学报（英文版） 年份：2009
...
[期刊论文] 作者：Rong-rui WEI,Dan-ni SUN,Hong YANG,Juan YAN,Xiong ZHANG,Xing-ling ZHENG,Xu-hong FU,Mei-yu GENG,Xun HUANG,
来源：中国药理学报（英文版） 年份：2018
Aggregated metastatic cancer cells,referred to as circulating tumor cell (CTC) clusters,are present in the blood of cancer patients and contribute to cancer met...
[期刊论文] 作者：Tian Fang,Dan-dan Liu,He-ming Ning,Dan Liu,Jing-ya Sun,Xiao-jing Huang,Yu Dong,Mei-yu Geng,Shi-feng Yun,
来源：中国药理学报（英文版） 年份：2018
Modified citrus pectin (MCP) is a carbohydrate enriched complex,which has been implicated in cancer treatment and prevention.However,the effects of MCP on urina...
SAF-189s,a potent new-generation ROS1 inhibitor,is active against crizotinib-resistant ROS1 mutant-d
[期刊论文] 作者：Yin-chun Ji,De-qiao Sun,Xia Peng,Ying-lei Gao,Yan-fen Fang,Xing-dong Zhao,Wei-bo Wang,Jian Ding,Mei-yu Geng,
来源：中国药理学报（英文版） 年份：2021
The ROS1 fusion kinase is an attractive antitumor target.Though with significant clinical efficacy,the well-known first-generation ROS1 inhibitor(ROS1 i)crizotinib inevitably developed acquired resistance due to secondary point mutations in......
,CUDC-907 displays potent antitumor activity against human pancreatic adenocarcinoma in vitro and in
[期刊论文] 作者：Yang,Xiao-wei Xu,Zong-long Hu,Juan Yan,Xing-ling Zheng,Rong-rui Wei,Zhu-qing Zhang,Shi-rui Tang,Mei-yu Geng,
来源：中国药理学报（英文版） 年份：2019
Pancreatic adenocarcinoma is a highly malignant cancer that often involves a deregulation of c-Myc.It has been shown that c-Myc plays a pivotal role in the regu...
,Marine-derived chromopeptide A, a novel class Ⅰ HDAC inhibitor, suppresses human prostate cancer ce
[期刊论文] 作者：Hong-chun LIU,Min-min ZHANG,Yu-Chih LIU,Chen-hua ZHANG,Yi SU,Yan-yan SHEN,Yue-wei GUO,Ai-jun SHEN,Mei-yu GENG,
来源：中国药理学报（英文版） 年份：2017
Histone deacetylases (HDACs),especially HDAC1,2,3 and 4,are abundantly expressed and over-activated in prostate cancer that is correlated with the poor prognosi...
,Establishment of platform for screening insulin-like growth factor-1 receptor inhibitors and evalua
[期刊论文] 作者：,Hua XIE,Ting PENG,Xiao-feng LIU,Xian-liang XIN,Xun HUANG,Si-meng CHEN,Hong-yan LIU,Hong-lin LI,Mei-yu GENG,
来源：中国药理学报（英文版） 年份：2011
...
SAF-248,a novel PI3Kδ-selective inhibitor,potently suppresses the growth of diffuse large B-cell lym
[期刊论文] 作者：Xing-dong Zhao,Yi-ming Sun,Dong-ze Lin,Yi Chen,Yu-xiang Wang,Zu-wen Zhou,Yan-xin Liu,Li-hua Jiang,Mei-yu Geng,
来源：中国药理学报（英文版） 年份：2022
PI3Kδ is expressed predominately in leukocytes and overexpressed in B-cell-related malignances.PI3Kδ has been validated as a promising target for cancer therapy,and specific PI3Kδ inhibitors were approved for clinical practice.However,th......
[期刊论文] 作者：Lu,Lin-Jiang Tong,Yan Li,Tao Zhang,Qiu-Ju Xun,Fang Feng,Yu-Zhe Chen,Yi Su,Yan-Yan Shen,Yi Chen,Mei-Yu Geng,
来源：中国药理学报（英文版） 年份：2018
Colony-stimulating factor 1 receptor (CSF1R) plays a critical role in promoting tumor progression in various types of tumors.Here,we identified D2923 as a novel...
A novel tricyclic BTK inhibitor suppresses B cell responses and osteoclastic bone erosion in rheumat
[期刊论文] 作者：Liu,Xiao-qian Yang,Feng-hua Zhu,Yue-teng Huang,Shi-qi Cao,Fang-ming Yang,Zi-lan Song,Jian Ding,Mei-yu Geng,
来源：中国药理学报（英文版） 年份：2021
Rheumatoid arthritis (RA) is characterized by joint leukocyte infiltration,synovial inflammation and bone damage result from osteoclastogenesis.Bruton\'s tyrosine kinase (BTK) is a key regulator of B cell receptor (BCR) and Fc gamma recepto......
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