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An Improved Synthesis of Methyl Protodioscin:A Direct E-ring Opening by BF3-Et2O/Ac2O from Dioscin E
[会议论文] 作者：Bo Wang,Yang Liu,Maosheng Cheng,
来源：第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会 年份：2012
A direct E-ring opening of dioscin ester by BF3-Et2O/Ac2O was studied,and methyl protodioscin was synthesized from dioscin ester in three steps with a total yield of 44%.The details of the E-ring open...
Structure-based virtual screening for low molecular weight chemical starting points as p21-activated
[会议论文] 作者：Ruijuan Li,Wanxu Huang,Jian Wang,Maosheng Cheng,
来源：第十三届全国计算机化学学会会议 年份：2015
P21-activated kinase 4(PAK4),a serine/threonine protein kinase,was originally identified as an effector protein for Rho-family GTPases.1 PAK4 plays an important role in regulating cytoskeletal organiz...
[会议论文] 作者：Gaofei Wei,Shuai Wang,Li Ren,Yang Liu,Maosheng Cheng,
来源：全国药物化学学术会议暨第四届中英药物化学学术会议 年份：2013
...
[会议论文] 作者：Ruijuan Li,Jian Wang,Zhen Xu,Maosheng Cheng,Jian Zhang,Feng Li,
来源：全国药物化学学术会议暨第四届中英药物化学学术会议 年份：2013
...
[会议论文] 作者：Ruijuan Li,Jian Wang,Zhen Xu,Jian Zhang,Maosheng Cheng,Feng Li,
来源：全国药物化学学术会议暨第四届中英药物化学学术会议 年份：2013
...
[会议论文] 作者：Chenzhou Hao,Shuai Song,Jing Guo,Qiaoling Zhang,Maosheng Cheng,Dongmei Zhao,
来源：2015年全国药物化学学术会议暨第五届中英药物化学学术会议 年份：2015
p21-activated kinases(PAKs)are a family of serine/threonine kinases that act downstream of Rho GTPases,Rac and Cdc42....
[会议论文] 作者：Zhuang Hou,Xinxin Zhang,Fengran Li,Yang Liu,Maosheng Cheng,Chun Guo,
来源：2015年全国药物化学学术会议暨第五届中英药物化学学术会议 年份：2015
Carbonic anhydrases(CAs)are a family of enzymes comprised of 16 isoenzymes that can catalyze the hydration of carbon dioxide to a proton and bicarbonate anion and therefore play an important role in t...
Functionalization of the Catalytic Core of 10-23 DNAzyme with Protein-like Functional Groups Promise
[会议论文] 作者：Junlin He,Qi Wang,Xia Wei,Yamin Li,Keliang Liu,Di Zhang,Maosheng Cheng,
来源：第三届中国小核酸技术与应用学术会议 年份：2011
...
Functionalization of the Catalytic Core of 10-23 DNAzyme with Protein-like Functional Groups Promise
[会议论文] 作者：Junlin He,Di Zhang,Qi Wang,Xia Wei,Yamin Li,Maosheng Cheng,Keliang Liu,
来源：第三届中国小核酸技术与应用学术会议 年份：2011
...
[会议论文] 作者：Di Zhang,Qi Wang,Xia Wei,Yaming Li,Maosheng Cheng,Junlin He,Keliang Liu,
来源：第一届亚洲小核酸会议暨第二届中国小核酸技术与应用学术会议 年份：2009
...
[会议论文] 作者：Dongju Lin,Xiucai Guo,Huiyuan Gao,Li Cheng,Maosheng Cheng,Shaojiang Song,Ying Peng,Jiang Zheng,
来源：2015第11届全国药物和化学异物代谢学术会议 年份：2015
Furanoid 8-epidiosbulbin E acetate (EEA) is a major constituent of herbal medicine Dioscorea bulbifera L.(DB), a traditional Chinese medicine herb....
[会议论文] 作者：Qi Wang,Yang Liu,Wei Rong,Jianping Yu,Di Zhang,Maosheng Cheng,Keliang Liu,Junlin He,
来源：第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会 年份：2012
Residue replacement of functional nucleic acids is the first choice for their structure-activity relationship and better performance,in the absence of active conformation.Two small DNAzymes,10-23 as g...
Design, Synthesis and Biological Evaluation of 6-(2,6-dichloro-3,5-dimethoxyphenyl)-4-Substituted-1H
[会议论文] 作者：Zhen Zhang,Dongmei Zhao,Yang Dai,Maosheng Cheng,Meiyu Geng,Yuchi Ma,Jing Ai,Bing Xiong,Jingkang Shen,
来源：2016年长三角药物化学研讨会 年份：2016
Tyrosine kinase fibroblast growth factor receptor (FGFR),which is aberrant in various cancer types,is a promising target for cancer therapy[1-4].Thus,discovery of potent and selective FGFR inhibitors...
[会议论文] 作者：Baohua Zheng,Huihui Chong,Deqiang Cao,Xifeng Jiang,Xiaoyu Xu,Guiying Zhang,Yuxian He,Maosheng Cheng,Keliang,
来源：第十三届中国国际多肽大会 年份：2014
Peptides derived from HIV-1 gp41 N-terminal heptad repeat(NHR)region(N-peptide)are weak fusion inhibitors due to their tendency to aggregate instead of form...
Stereoselective and Regioselective Preparations of C-Pentopyranosides and Formal Synthesis of Omarig
[会议论文] 作者：Tongchao Liu,Jian Hou,You Li,Jianpeng Liang,Bing Xiong,Chungang Li,Guohua Chen,Maosheng Cheng,Dongmei,
来源：2016年长三角药物化学研讨会 年份：2016
...
Au(Ⅰ)-Catalyzed 6-endo-dig Cyclizations of Aromatic 1,5-Enynes to 2-(Naphthalen-2-yl)anilines Leadin
[期刊论文] 作者：Jiayue Fu,Bingbing Li,Xiugui Wang,Qida Liang,Xiaoshi Peng,Lu Yang,Tao Wan,Xinxiu Wang,Bin Lin,Maosheng Cheng,
来源：中国化学（英文版） 年份：2022
A gold(Ⅰ)-catalyzed 6-endo-dig cyclization of aromatic 1,5-enynes was developed to synthesize 2-(naphthalen-2-yl)anilines.The func-tional group tolerance of this cyclization was examined systematically and a possible mechanism was proposed......
Structurally defined tandem-responsive nanoassemblies composed of dipeptide-based photosensitive der
[期刊论文] 作者：Mengchi Sun,Hailun Jiang,Tian Liu,Xiao Tan,Qikun Jiang,Bingjun Sun,Yulong Zheng,Gang Wang,Yang Wang,Maosheng Cheng,
来源：药学学报（英文版） 年份：2022
Substantial progress in the use of chemo-photodynamic nano-drug delivery systems(nano-DDS)for the treatment of the malignant breast cancer has been achieved.The inability to customize pre-cise nanostructures,however,has limited the therapeu......
[期刊论文] 作者：Peng Wei,Bo Liu,Ruifeng Wang,Yinglei Gao,Lanlan Li,Yuchi Ma,Zhiwei Qian,Yuelei Chen,Maosheng Cheng,Meiyu,
来源：药学学报（英文版） 年份：2019
Genomic alterations are commonly found in the signaling pathways of fibroblast growth factor receptors (FGFRs).Although there is no selective FGFR inhibitors in...
Methyltransferase like 13 mediates the translation of Snail in head and neck squamous cell carcinoma
[期刊论文] 作者：Xiaochen Wang,Kang Li,Yuehan Wan,Fangfang Chen,Maosheng Cheng,Gan Xiong,Ganping Wang,Shuang Chen,Zhi,
来源：国际口腔科学杂志:英文版 年份：2021
Methyltransferase like 13(METTL13),a kind of methyltransferase,is implicated in protein binding and synthesis.The upregulation of METTL13 has been reported in a variety of tumors.However,little was known about its potential function in head......
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