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[期刊论文] 作者：Yu-jia XU,Li-jie REN,Zu-bin ZHANG,Xin XU,Bi-yin CAO,Ke-sheng DAI,Li ZHU,Qi FANG,
来源：中国药理学报（英文版） 年份：2017
The signal transducer and activator of transcription 3 (STAT3) plays a critical role in platelet functions.This study sought to understand the effects of the ST...
TRIM25 activates AKT/mTOR by inhibiting PTEN via K63-linked polyubiquitination in non-small cell lun
[期刊论文] 作者：Yuan-ming He,Xiu-min Zhou,Shuo-yi Jiang,Zu-bin Zhang,Bi-yin Cao,Jin-bao Liu,Yuan-ying Zeng,Jun Zhao,Xin-liang,
来源：中国药理学报（英文版） 年份：2022
The PTEN/AKT/mTOR signaling pathway is frequently dysregulated in non-small cell lung cancer(NSCLC),but the mechanisms are not well-understood.The present study found that the ubiquitin ligase TRIM25 is highly expressed in NSCLC tissues and......
,RNF6 promotes myeloma cell proliferation and survival by inducing glucocorticoid receptor polyubiqu
[期刊论文] 作者：Ying Ren,Xin Xu,Chen-yu Mao,Kun-kun Han,Yu-jia Xu,Bi-yin Cao,Zu-bin Zhang,Gautam Sethi,Xiao-wen Tang,,
来源：中国药理学报（英文版） 年份：2020
RNF6,a RING-type ubiquitin ligase,has been identified as an oncogene in various cancers but its role in multiple myeloma (MM) remains elusive.In the present stu...
[期刊论文] 作者：Xue-han Chen,Yu-jia Xu,Xiao-ge Wang,Peng Lin,Bi-yin Cao,Yuan-ying Zeng,Qi Wang,Zu-bin Zhang,Xin-liang,
来源：中国药理学报（英文版） 年份：2019
c-Maf is a critical oncogenic transcription factor that contributes to myelomagenesis.Our previous studies demonstrated that the deubiquitinase USP5 stabilizes...
TP53-induced glycolysis and apoptosis regulator alleviates hypoxia/ischemia-induced microglial pyrop
[期刊论文] 作者：Lan-Lan Tan,Xiao-Lu Jiang,Li-Xiao Xu,Gen Li,Chen-Xi Feng,Xin Ding,Bin Sun,Zheng-Hong Qin,Zu-Bin Zhang,
来源：中国神经再生研究（英文版） 年份：2021
Our previous studies have demonstrated that TP53-induced glycolysis and apoptosis regulator (TIGAR) can protect neurons after cerebral ischemia/reperfusion. How...
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