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Enhancing the Sensitivity of Pharmacophore-Based Virtual Screening by Incorporating Customized ZBG F
[会议论文] 作者：Xuben Hou,Renshuai Liu,Yi Zhou,Hao Fang,
来源：2015年全国药物化学学术会议暨第五届中英药物化学学术会议 年份：2015
As key regulators in epigenetic regulation,the human histone deacetylases(HDACs)have been identified as a drug target for the treatment of several cancers[1].Proper reorganization of zinc binding grou...
Identification of Novel Lymphoid Tyrosine Phosphatase Inhibitors Using Pharmacophore-based and Docki
[会议论文] 作者：Xuben Hou,Renxiao Wang,Xiao Yu,Hao Fang,
来源：全国药物化学学术会议暨第四届中英药物化学学术会议 年份：2013
The lymphoid tyrosine phosphatase LYP,encoded by the PTPN22 gene,is a critical regulator of signaling in T cells.A single-nucleotide polymorphism(SNP)in the PTPN22 gene correlates with various autoimm...
Protein Flexibility in Docking-based Virtual Screening:Discovery of Novel Lymphoid-specific Tyrosine
[会议论文] 作者：Xuben Hou,Kangshuai Li,Jin-peng Sun,Hao Fang,
来源：2015年全国药物化学学术会议暨第五届中英药物化学学术会议 年份：2015
Incorporating protein flexibility is a major challenge for docking-based virtual screening[1].With an increasing number of available crystal structures,ensemble docking with multiple protein structure...
[期刊论文] 作者：Meng Liu,Shan Gao,Reham M.Elhassan,Xuben Hou,Hao Fang,
来源：药学学报（英文版） 年份：2021
Encoded by PTPN11,the SHP2(Src homology-2 domain-containing protein tyrosine phosphatase-2)is widely recognized as a carcinogenic phosphatase.As a promising anti-cancer drug target,SHP2 regulates many signaling pathways such as RAS-RAF-ERK,......
[会议论文] 作者：Huansheng Fu,Xuben Hou,Lei Wang,Yanyan Dun,Xinying Yang,Hao Fang,
来源：2015年全国药物化学学术会议暨第五届中英药物化学学术会议 年份：2015
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Design,synthesis and preliminary biological evaluation of pyrrolidine derivatives as Mcl-1 inhibitor
[会议论文] 作者：Yichao Wan,Junhua Wang,Feng'e Sun,Minglu Chen,Xuben Hou,Hao Fang,
来源：2015年全国药物化学学术会议暨第五届中英药物化学学术会议 年份：2015
The B-cell lymphoma(Bcl-2)family proteins are potential targets for cancer treatment.In our studies,a series of pyrrolidine derivatives were developed as potent myeloid cell leukemia sequence 1(Mcl-1)...
[期刊论文] 作者：Jintong Du,Jing Guo,Dongwei Kang,Zhihong Li,Guan Wang,Jianbing Wu,Zhen Zhang,Hao Fang,Xuben Hou,Zhangjian,
来源：中国化学快报（英文版） 年份：2020
Great success has been witnessed in last decades,some new techniques and strategies have been widely used in drug discovery.In this roadmap,several representati...
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