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[会议论文] 作者：Weidong Le,
来源：The 6th FAONS Congress and 11th Biennial Conference of CNS(第 年份：2015
Amyotrophic lateral sclerosis(ALS)is an adult-onset devastating neurodegenerative disease resulted from the selective death of motor neurons(MNs)associated with abnormal protein aggregation in the spi...
[会议论文] 作者：Weidong Le,
来源：第九届北京睡眠高峰论坛 年份：2018
Research interests帕金森病的临床和病理特征1.Nigral DA neuron loss2.Striatal DA level decrease3.Lewy Body and protein aggregation4.Neuroinf lammation midbrainSle...
[会议论文] 作者：Weidong Le,
来源：2013首届世界健康大会 年份：2013
Embryonic stem (ES) cell-based therapy is a promising treatment for neurodegenerative diseases.Although it is well established that ES cells have the potential to differentiate into dopamine neurons,t...
Gene regulation of dopamine neuron differentiation and prevention of teratoma formation from embryon
[会议论文] 作者：Weidong Le,
来源：第九届广州国际干细胞与再生医学论坛暨第五届中国再生细胞生物学年会 年份：2016
...
[会议论文] 作者：Weidong Le,
来源：Joint Symposium of 2016 International Neural Regeneration Sy 年份：2016
Parkinsons disease (PD) is the second most common neurodegenerative disease in adults mainly manifesting movement disorder symptoms.The loss of dopamine (DA) neurons in the substantia nigra (SN) is th...
[期刊论文] 作者：Weidong Le,
来源：神经科学通报（英文版） 年份：2015
The word autophagy is derived from the Greek roots “auto” (self) and “phagy” (eating) and broadly refers to cellular catabolic processes.Autophagy regulates important biological functions,such as cell survival,cell death,cell metabolism......
Dopamine neuron degeneration induced by MPP^＋ is independent of CED-4 pathway in Caenorhabditis eleg
[期刊论文] 作者：PuPu Weidong Le,
来源：细胞研究：英文版 年份：2008
...
[期刊论文] 作者：Song Li,Weidong Le,,
来源：Neuroscience Bulletin 年份：2017
Parkinson’s disease(PD)is the second most common neurodegenerative disorder affecting more than 1%of the older population.Histopathologically,PD is characteriz...
[期刊论文] 作者：Song Li,Weidong Le,,
来源：Neuroscience Bulletin 年份：2017
Parkinson’s disease(PD)is the second most common neurodegenerative disease worldwide.Since its first description as a neurological disorder by James Parkinson(...
[期刊论文] 作者：Peizhou Liang,Weidong Le,,
来源：Neuroscience Bulletin 年份：2015
Autophagy plays an important role in maintaining the cellular homeostasis. One of its functions is to degrade unnecessary organelles and proteins for energy rec...
[期刊论文] 作者：Yan-Ning Rui,Weidong Le,
来源：神经科学通报（英文版） 年份：2015
Proteostasis is critical for neuronal maintenance and survival,and its imbalance leads to neurodegeneration with the hallmark of protein misfolding and aggregation[1].Macroautophagy becomes a major route for the clearance of protein aggrega......
[期刊论文] 作者：Tianbai Li,Weidong Le,
来源：神经科学通报（英文版） 年份：2020
Parkinson\'s disease (PD) is a complex neurodegenerative disorder with no cure in sight.Clinical challenges of the disease include the inability to make a definitive diagnosis at the early stages and difficulties in predicting the disease p......
[期刊论文] 作者：Jack Jia,Weidong Le,
来源：神经科学通报（英文版） 年份：2015
...
[期刊论文] 作者：Ying Wang,Zhaofei Yang,Weidong Le,,
来源：Neuroscience Bulletin 年份：2017
Parkinson’s disease(PD) is the second most common age-related neurodegenerative disorder after Alzheimer’s disease. To date, the clinical diagnosis of PD is p...
[期刊论文] 作者：Qian Xiao,Sheng Chen,Weidong Le,,
来源：Neuroscience Bulletin 年份：2004
阜阳市局 ￡4a 局长——_MINtkMMtgj’＃lnH＄B——q.M——D收束志不他只邀狲位J则【科校为先导推动地租工作.B为广为戳民U用凶盼引眯B.习.互们羹宽.互狈槽竺汹IAn.刊 办好杂志。必...
[期刊论文] 作者：Weidong Le,Jie Dong,Song Li,Amos D.Korczyn,,
来源：Neuroscience Bulletin 年份：2017
Parkinson’s disease(PD) is a complex neurodegenerative disease with progressive loss of dopamine neurons. PD patients usually manifest a series of motor and no...
[期刊论文] 作者：Song Li,Congcong Jia,Tianbai Li,Weidong Le,
来源：神经科学通报（英文版） 年份：2021
Parkinson\'s disease (PD),the second most common neurodegenerative disease,is clinically charac-terized by both motor and non-motor symptoms.Although overall great achievements have been made in elucidating the etiology and pathogenesis of ......
[期刊论文] 作者：Yufei Liu,Long Niu,Xinyao Liu,Cheng Cheng,Weidong Le,
来源：神经科学通报（英文版） 年份：2021
Parkinson\'s disease(PD)is the second most common neurodegenerative disease,which manifests with both motor and non-motor symptoms.Circadian rhythm dysregulation,as one of the most challenging non-motor features of PD,usually appears long b......
Recent Progress in Non-motor Features of Parkinson’s Disease with a Focus on Circadian Rhythm Dysreg
[期刊论文] 作者：Yufei Liu,Long Niu,Xinyao Liu,Cheng Cheng,Weidong Le,
来源：神经科学通报:英文版 年份：2021
Parkinson’s disease(PD)is the second most common neurodegenerative disease,which manifests with both motor and non-motor symptoms.Circadian rhythm dysregulation,as one of the most challenging non-motor features of PD,usually appears long b......
Histone deacetylase 6 delays motor neuron degeneration by ameliorating the autophagic flux defect in
[期刊论文] 作者：Sheng Chen,Xiao-Jie Zhang,Li-Xi Li,Yin Wang,Ru-Jia Zhong,Weidong Le,,
来源：Neuroscience Bulletin 年份：2015
Amyotrophic lateral sclerosis(ALS) is a fatal neurodegenerative disorder characterized by the selective loss of motor neurons. Abnormal protein aggregation and...
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