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[期刊论文] 作者：HUANG Gui-hua,QIN Qiu-ping,,
来源：中国药理学与毒理学杂志 年份：2013
OBJECTIVE The aim of this study was to validate an end-point colorimetric assay provided by Roche Diagnostics for the measurement of NAG in SD rats,beagle dogs...
[期刊论文] 作者：HUANG Gui-hua,QIN Qiu-ping,,
来源：中国药理学与毒理学杂志 年份：2013
OBJECTIVE To evaluate whether three assays,respectively,for the measurement of human C-reactive protein(CRP),haptoglobin(Hp) and total bile acid(TBA) were suita...
Method validation of C-reactive protein, total bile acids and haptoglobin in cynomolgus monkeys with
[会议论文] 作者：HUANG Gui-hua,QIN Qiu-ping,
来源：2013年(第三届)中国药物毒理学年会暨药物非临床安全性评价研究论坛 年份：2013
OBJECTIVE To evaluate whether three assays, respectively, for the measurement of human C-reactive protein (CRP), haptoglobin(Hp) and total bile acid (TBA) were suitable for the applications in cynomol...
Validation of a method for urine N-acetyl-β-D-glucosaminidase in SD rats, beagle dogs and cynomolgus
[会议论文] 作者：HUANG Gui-hua,QIN Qiu-ping,
来源：2013年(第三届)中国药物毒理学年会暨药物非临床安全性评价研究论坛 年份：2013
OBJECTIVE The aim of this study was to validate an end-point colorimetric assay provided by Roche Diagnostics for the measurement of NAG in SD rats, beagle dogs and cynomolgus monkeys with Cobas 6000...
[期刊论文] 作者：GAO Jin-li,HUANG Gui-hua,QIN Qiu-ping,
来源：2013年(第三届)中国药物毒理学年会暨药物非临床安全性评价研究论坛 年份：2013
OBJECTIVE To validate an ELISA method for the determination of adiponectin in cynomolgus monkeys.The ELISA kit was commercially available, but originally designed for the measurement of adiponectin in...
Validation of two assays for determination of neutrophil oxidative burst and neutrophil phagocytosis
[期刊论文] 作者：CAO Yi-yi,HUANG Gui-hua,QIN Qiu-ping,,
来源：中国药理学与毒理学杂志 年份：2013
OBJECTIVCE To investigate the altered oxidative burst activity and phagocytic activity,respectively.METHODS Both PHAGOBURST assay,which determines the percentag...
Validation of two assays for determination of neutrophil oxidative burst and neutrophil phagocytosis
[会议论文] 作者：CAO Yi-yi,HUANG Gui-hua,QIN Qiu-ping,
来源：2013年(第三届)中国药物毒理学年会暨药物非临床安全性评价研究论坛 年份：2013
OBJECTIVCE To investigate the altered oxidative burst activity and phagocytic activity, respectively.METHODS Both PHAGOBURST assay, which determines the percentage of neutrophils that undergo an oxida...
[期刊论文] 作者：HU Miao-miao,YU Hong,Elaine GORDON,QIN Qiu-ping,QIAO Jun-wen,JING Yi,LU Jing,REN Jin,
来源：2013年(第三届)中国药物毒理学年会暨药物非临床安全性评价研究论坛 年份：2013
CDSER (Centre for Drug Safety Evaluation and Research) perform GLP Toxicology studies according to SFDA, FDA, Japan and OECD guidelines.To help achieve this, the Provantis Computerised System for Toxi...
Evaluation of human monoclonal antibody toxicity,toxicokinetics and immunogenicity in cynomolgus mon
[期刊论文] 作者：YU Hong,Patricia RYAN,LIANG Mei-na,ZHENG Wei-jun,QIN Qiu-ping,Dale THURMAN,QIAO Jun-wen,REN Jin,,
来源：中国药理学与毒理学杂志 年份：2013
OBJECTIVE The aim of this study was to characterize the toxicity of the antibody and in particular,the exposure-response relationship of the immune-mediated tox...
Evaluation of human monoclonal antibody toxicity, toxicokinetics and immunogenicity in cynomolgus mo
[会议论文] 作者：YU Hong,Patricia RYAN,LIANG Mei-na,ZHENG Wei-jun,QIN Qiu-ping,Dale THURMAN,QIAO Jun-wen,REN Jin,
来源：2013年(第三届)中国药物毒理学年会暨药物非临床安全性评价研究论坛 年份：2013
OBJECTIVE The aim of this study was to characterize the toxicity of the antibody and in particular, the exposure-response relationship of the immune-mediated toxicity between these two dose regimens.M...
Evaluation of cisplatin-induced toxicity in cynomolgus macaques including assessment of potential bi
[期刊论文] 作者：YU Hong,Sonya GALES,ZHENG Wei-jun,QIN Qiu-ping,Dale THURMAN,QIAO Jun-wen,REN Jin,CHEN Ya-fei,Russell,
来源：中国药理学与毒理学杂志 年份：2013
OBJECTIVE Cisplatin-induced nephrotoxicity has been characterized previously in animals and humans.Two studies were conducted in cynomolgus macaques to assess t...
Evaluation of cisplatin-induced toxicity in cynomolgus macaques including assessment of potential bi
[会议论文] 作者：YU Hong,Lew KINTER,Nigel BARRASS,Sonya GALES,ZHENG Wei-jun,QIN Qiu-ping,Dale THURMAN,QIAO Jun-wen,REN,
来源：2013年(第三届)中国药物毒理学年会暨药物非临床安全性评价研究论坛 年份：2013
OBJECTIVE Cisplatin-induced nephrotoxicity has been characterized previously in animals and humans.Two studies were conducted in cynomolgus macaques to assess the nephrotoxicity of cisplatin and to co...
Evaluation of imipenem toxicity in cynomolgus macaques including assessment of biomarkers of renal d
[期刊论文] 作者：YU Hong,Sonya GALES,ZHENG Wei-jun,QIN Qiu-ping,Dale THURMAN,HU Li-ping,QIAO Jun-wen,REN Jin,CHEN Ya-fei,
来源：中国药理学与毒理学杂志 年份：2013
OBJECTIVE To assess the nephrotoxicity of imipenem and to correlate the pathogenesis of lesions in the kidney with changes in urinary biomarkers of kidney toxic...
[期刊论文] 作者：,Sonya GALES,Eva LENZ,Dan WESTON,Ian WILSONB,Tony PARRY,Helen POWELL,Dale THURMAN,QIAO Jun-wen,QIN Qiu-ping,
来源：中国药理学与毒理学杂志 年份：2013
Paracetamol(acetominophen,APAP) was administered orally in a rising dose protocol to 2 male and 2 female Cynomolgus monkeys to determine the Maximum Tolerated d...
Evaluation of imipenem toxicity in cynomolgus macaques including assessment of biomarkers of renal d
[会议论文] 作者：YU Hong,Russell BIALECKI,Lew KINTER,Nigel BARRASS,Sonya GALES,ZHENG Wei-jun,QIN Qiu-ping,Dale THURMAN,
来源：2013年(第三届)中国药物毒理学年会暨药物非临床安全性评价研究论坛 年份：2013
OBJECTIVE To assess the nephrotoxicity of imipenem and to correlate the pathogenesis of lesions in the kidney with changes in urinary biomarkers of kidney toxicity.METHODS Study #1, 11 monkeys (2-3/se...
[会议论文] 作者：YU Hong,QIAO Jun-wen,QIN Qiu-ping,REN Jin,Nigel BARRASS,Sonya GALES,Eva LENZ,Dan WESTON,Ian WILSONB,Tony,
来源：2013年(第三届)中国药物毒理学年会暨药物非临床安全性评价研究论坛 年份：2013
Paracetamol (acetominophen, APAP) was administered orally in a rising dose protocol to 2 male and 2 female Cynomolgus monkeys to determine the Maximum Tolerated dose (MTD) for subsequent toxicology in...
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