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Research and Development of Active Ingredients from Chinese medicine for Novel Targeting Drug Delive
[会议论文] 作者：Meiwan Chen,
来源：第三届国际纳米药物大会 ChinaNanomedicine 2018 The 3rd International Con 年份：2018
We developed a series of multifunctional mixed micellar systems were developed to target to liver cancer,by means of glycyrrhetinic acid receptors abounding specifically in liver cancer cell surface,a...
Paclitaxel and Cryptotanshinone Loaded Temporal-controlled Nanoparticles for Combinatorial Cancer Th
[会议论文] 作者：Shengpeng Wang,Meiwan Chen,Yitao Wang,
来源：第十四届全国中药和天然药物学术研讨会暨第十三届中药全球化联盟大会 年份：2014
...
Paclitaxel and Cryptotanshinone Loaded Temporal-controlled Nanoparticles for Combinatorial Cancer Th
[会议论文] 作者：Shengpeng Wang,Meiwan Chen,Yitao Wang,
来源：第十四届全国中药和天然药物学术研讨会暨第十三届中药全球化联盟大会 年份：2014
Combination therapy has emerged as a promising strategy for treating multidrug resistant (MDR) cancer.In the previous studies, we found that cryptotanshinone (CPT), an active compound from Salvia milt...
[会议论文] 作者：Yingqi Xu,Shengpeng Wang,Meiwan Chen,
来源：2016年中国药物制剂大会、中国药学会药剂专业委员会2016年学术年会、中国化学制药工业协会固体制剂专业委员会2016年 年份：2016
Mitochondria are important targets for the intracellular delivery of drugs and DNA.For mitochondria-targeting delivery,a mitochondriotropic molecule,triphenylphosphonium(TPP)was applied to the synthes...
Synthesis,characterization and cytotoxicity evaluation of Redox-sensitive Pluronic F127-tocopherol m
[会议论文] 作者：Yuling Liu,Hui Li,Meiwan Chen,
来源：2016年中国药物制剂大会、中国药学会药剂专业委员会2016年学术年会、中国化学制药工业协会固体制剂专业委员会2016年 年份：2016
Pluronic F127,an amphiphilic triblock copolymer,has been shown to have great potential for drug delivery,as it is able to incorporate with hydrophobic drugs and self-assemble into nano-size micelles....
Nanoscale Metal-Organic Particles (NMOPs) with Rapid Clearance for MR Imaging Guided Photothermal Th
[会议论文] 作者：Yu Yang,Zhuang Liu,Meiwan Chen,
来源：第十一届中美华人纳米论坛 年份：2016
...
Tanshinone IIA Loaded TPGS-g-PLGA/Pluronic F68 Mixed Micelles to Improve its Bioavailability and Ant
[会议论文] 作者：Jinming Zhang,Lishuai Ma,Yitao Wang,Meiwan Chen,
来源：第九届中美华人纳米论坛 年份：2014
...
Glycyrrhetinic Acid-Decorated and Reduction-Sensitive Micelles for Enhancing Bioavailability and Ant
[会议论文] 作者：Fengqian Chen,Jinming Zhang,Meiwan Chen,Yitao Wang,
来源：第十四届全国中药和天然药物学术研讨会暨第十三届中药全球化联盟大会 年份：2014
...
[会议论文] 作者：Jinming Zhang,Ruie Chen,Meiwan Chen,Yitao Wang,
来源：第十四届全国中药和天然药物学术研讨会暨第十三届中药全球化联盟大会 年份：2014
...
Bioreducible Core-Crosslinked Amphiphilic Copolymeric Micelles for Delivery of Tetrandrine in Cancer
[会议论文] 作者：Yuee Cai,Jinming Zhang,Yitao Wang,Meiwan Chen,
来源：纳米药物及纳米生物技术国际学术大会暨中国药学会纳米药物专业委员会成立大会 年份：2015
...
[会议论文] 作者：Shengpeng Wang,Jinming Zhang,Yitao Wang,Meiwan Chen,
来源：纳米药物及纳米生物技术国际学术大会暨中国药学会纳米药物专业委员会成立大会 年份：2015
...
Bioreducible Core-Crosslinked Amphiphilic Copolymeric Micelles for Delivery of Tetrandrine in Cancer
[会议论文] 作者：Yuee Cai,Jinming Zhang,Yitao Wang,Meiwan Chen,
来源：纳米药物及纳米生物技术国际学术大会暨中国药学会纳米药物专业委员会成立大会 年份：2015
It is reported that hydrophobic drugs encapsulated in the core of polymeric micelles are released to the cell membrane before internalization, which limits the application of polymeric micelles....
A Novel Fluorescent Potassium Ion:In Situ Investigating the relationship between Mitochondrial K+and
[会议论文] 作者：Guangjie Song,Di Jiang,Yanqing Tian,Meiwan Chen,
来源：第十一届全国化学生物学学术会议 年份：2019
Intracellular K+plays an important role in apoptotic process.However,real-time concentration changes of mitochondrial K+during cell apoptosis remained unknown,thus the relationship between apoptosis a...
[会议论文] 作者：Jinming Zhang,Ruie Chen,Meiwan Chen,Yitao Wang,
来源：第十四届全国中药和天然药物学术研讨会暨第十三届中药全球化联盟大会 年份：2014
Targeted drug delivery coupled with rapid drug release in cytoplasm is a powerful strategy to enhance efficacy and reduce off-target effects of anti-cancer drugs.Herein, we developed a dual-functional...
Glycyrrhetinic Acid-Decorated and Reduction-Sensitive Micelles for Enhancing Bioavailability and Ant
[会议论文] 作者：Fengqian Chen,Jinming Zhang,Meiwan Chen,Yitao Wang,
来源：第十四届全国中药和天然药物学术研讨会暨第十三届中药全球化联盟大会 年份：2014
In the present study, we developed a dual-functional biodegradable micellar system named glycyrrhetinic acid-poly (ethylene glycol)-graft-poly(lactic-co-glycolic acid) polymers (GA-PEG-SS-PLGA) to enh...
Pluronic F68 Conjugate Linoleic Acid Polymeric Micelles for Gambogic Acid Delivery In Cancer Therapy
[会议论文] 作者：Yingqi Xu,Xiaobin Fang,Yitao Wang,Meiwan Chen,
来源：纳米药物及纳米生物技术国际学术大会暨中国药学会纳米药物专业委员会成立大会 年份：2015
Pluronic F68 is a well-known amphiphilic block copolymer consisting of hydrophobic propylene oxide units and hydrophilic ethylene oxide.It has attracted many attentions in the drug delivery field due...
[会议论文] 作者：Shengpeng Wang,Jinming Zhang,Yitao Wang,Meiwan Chen,
来源：纳米药物及纳米生物技术国际学术大会暨中国药学会纳米药物专业委员会成立大会 年份：2015
MicroRNAs (miRNAs) play critical roles in modulating the oncogenic pathways that are involved in the resistance to cancer treatments.Several studies have reported that miR-542-3p serves as a potent tu...
Non-ionic surfactant vesicles simultaneously enhances the anti-tumor activitiy and reduces the toxic
[会议论文] 作者：Hui Li,Meiwan Chen,Shengpeng Wang,Yitao Wang,
来源：2012年中国药物制剂大会——中国药学会药剂专业委员会年会、亚洲阿登制药技术研讨会暨国际控释协会中国分会年会 年份：2012
The objective of the present study was to prepare cantharidin entrapped non-ionic surfactant vesicle (noisome) and evaluate the potential in enhancing the in vitro and in vivo anti-tumor activities an...
[会议论文] 作者：Jinming Zhang,Yingbo Li,Meiwan Chen,Yitao Wang,
来源：中国微米纳米技术学会纳米科学技术分会第三届年会暨2014全国纳米生物与医学学术会议 年份：2014
Despite the significant advantages of nano-micellar systems on drug delivery,the poor therapeutic outcome in clinic is ascribed to inefficient tumor uptake and poor intracellular drug release.Plumbagi...
Tanshinone IIA Loaded TPGS-g-PLGA/Pluronic F68 Mixed Micelles to Improve its Bioavailability and Ant
[会议论文] 作者：Jinming Zhang,Lishuai Ma,Yitao Wang,Meiwan Chen,
来源：第九届中美华人纳米论坛 年份：2014
Tanshinone IIA (TAN) has few clinical applications for anti-cancer therapy mainly due to its high lipophicity,active drug efflux mediated by permeability glycoprotein (P-gp),and poor bioavailability.T...
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